6C6P

Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and NB-598

Summary for 6C6P

• Entry DOI: 10.2210/pdb6c6p/pdb
• Related: 6C6N 6C6R
• Descriptor: Squalene monooxygenase, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, (2E)-N-({3-[([3,3'-bithiophen]-5-yl)methoxy]phenyl}methyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine, ... (5 entities in total)
• Functional Keywords: cholesterol synthesis pathway, sqle, erg1, fad-dependent monooxygenase, squalene hydroxylase, squalene-2, 3-epoxidase, flavoprotein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 108566.12

Authors

Padyana, A.K.,Jin, L. (deposition date: 2018-01-19, release date: 2019-01-16, Last modification date: 2024-03-13)

• Primary citation: Padyana, A.K.,Gross, S.,Jin, L.,Cianchetta, G.,Narayanaswamy, R.,Wang, F.,Wang, R.,Fang, C.,Lv, X.,Biller, S.A.,Dang, L.,Mahoney, C.E.,Nagaraja, N.,Pirman, D.,Sui, Z.,Popovici-Muller, J.,Smolen, G.A.; Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase.; Nat Commun, 10:97-97, 2019; PubMed: 30626872; DOI: 10.1038/s41467-018-07928-x

Experimental method

X-RAY DIFFRACTION (2.5 Å)