6KJZ
Crystal structure of PDE4D catalytic domain complexed with compound 1
Summary for 6KJZ
Entry DOI | 10.2210/pdb6kjz/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | pde4 inhibitor, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 76672.16 |
Authors | Huang, Y.-Y.,He, X.,Luo, H.-B. (deposition date: 2019-07-23, release date: 2020-03-18, Last modification date: 2023-11-22) |
Primary citation | Liang, J.,Huang, Y.Y.,Zhou, Q.,Gao, Y.,Li, Z.,Wu, D.,Yu, S.,Guo, L.,Chen, Z.,Huang, L.,Liang, S.H.,He, X.,Wu, R.,Luo, H.B. Discovery and Optimization of alpha-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. J.Med.Chem., 63:3370-3380, 2020 Cited by PubMed: 32115956DOI: 10.1021/acs.jmedchem.0c00060 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.20000094865 Å) |
Structure validation
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