8KAI
Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 17nt target DNA
Summary for 8KAI
Entry DOI | 10.2210/pdb8kai/pdb |
Descriptor | RNA (34-MER), CRISPR-associated endonuclease Cas9/Csn1, DNA (25-MER), ... (6 entities in total) |
Functional Keywords | nuclease, rna binding protein/rna/dna, rna binding protein-rna-dna complex |
Biological source | Streptococcus pyogenes serotype M1 More |
Total number of polymer chains | 10 |
Total formula weight | 402861.79 |
Authors | |
Primary citation | Chen, J.,Chen, Y.,Huang, L.,Lin, X.,Chen, H.,Xiang, W.,Liu, L. Trans-nuclease activity of Cas9 activated by DNA or RNA target binding. Nat.Biotechnol., 2024 Cited by PubMed: 38811761DOI: 10.1038/s41587-024-02255-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.49 Å) |
Structure validation
Download full validation report![Download](https://newweb-cs.pages.dev/newweb/media/icons/dl.png)
![Download](https://newweb-cs.pages.dev/newweb/media/icons/dl.png)