4MZK
 
 | | Crystal Structure of MTIP from Plasmodium falciparum in complex with pGly[807,811], a stapled myoA tail peptide | | 分子名称: | Myosin A tail domain interacting protein, pGly[807,811], a stapled myoA tail peptide | | 著者 | Douse, C.H, Garnett, J.A, Maas, S.J, Cota, E, Tate, E.W. | | 登録日 | 2013-09-30 | | 公開日 | 2013-11-06 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein-Helix Interaction.
Acs Chem.Biol., 8, 2014
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5T92
 | | ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH (2E)-3-{4-[(1R)-2-(4-fluorophenyl)-6-hydroxy-1-methy l-1,2,3,4- tetrahydroisoquinolin-1-yl]phenyl}prop-2-enoic acid | | 分子名称: | (2E)-3-{4-[(1R)-2-(4-fluorophenyl)-6-hydroxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]phenyl}prop-2-enoic acid, Estrogen receptor | | 著者 | Kirby, C, Baird, J. | | 登録日 | 2016-09-09 | | 公開日 | 2017-03-29 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ER alpha + Breast Cancer.
J. Med. Chem., 60, 2017
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5T97
 | | ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH (2E)-3-(4-{(1R)-6-hydroxy-1-methyl-2-[4-(propan-2 -yl)phenyl]-1,2,3,4- tetrahydroisoquinolin-1-yl}phenyl)prop-2-enoic acid | | 分子名称: | (2E)-3-(4-{(1R)-6-hydroxy-1-methyl-2-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydroisoquinolin-1-yl}phenyl)prop-2-enoic acid, Estrogen receptor | | 著者 | Kirby, C.A, Baird, J. | | 登録日 | 2016-09-09 | | 公開日 | 2017-03-29 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ER alpha + Breast Cancer.
J. Med. Chem., 60, 2017
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7YYO
 | | Cryo-EM structure of an a-carboxysome RuBisCO enzyme at 2.9 A resolution | | 分子名称: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, Ribulose bisphosphate carboxylase large chain, ... | | 著者 | Mann, D, Evans, S.L, Bergeron, J.R.C. | | 登録日 | 2022-02-18 | | 公開日 | 2023-01-25 | | 最終更新日 | 2023-06-14 | | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | | 主引用文献 | Single-particle cryo-EM analysis of the shell architecture and internal organization of an intact alpha-carboxysome.
Structure, 31, 2023
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7BUY
 | | The crystal structure of COVID-19 main protease in complex with carmofur | | 分子名称: | 3C-like proteinase, DIMETHYL SULFOXIDE, hexylcarbamic acid | | 著者 | Zhao, Y, Zhang, B, Jin, Z, Liu, X, Yang, H, Rao, Z. | | 登録日 | 2020-04-08 | | 公開日 | 2020-04-29 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.
Nat.Struct.Mol.Biol., 27, 2020
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2J3E
 | | Dimerization is important for the GTPase activity of chloroplast translocon components atToc33 and psToc159 | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, T7I23.11 PROTEIN | | 著者 | Yeh, Y.-H, Kesavulu, M.M, Wu, S.-Z, Li, H.-M, Sun, Y.-J, Konozy, E.H, Hsiao, C.-D. | | 登録日 | 2006-08-21 | | 公開日 | 2007-03-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Dimerization is Important for the Gtpase Activity of Chloroplast Translocon Components Attoc33 and Pstoc159.
J.Biol.Chem., 282, 2007
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3EFK
 | | Structure of c-Met with pyrimidone inhibitor 50 | | 分子名称: | 5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(4-fluorophenyl)amino]-3-methylpyrimidin-4(3H)-one, Hepatocyte growth factor receptor | | 著者 | Bellon, S.F, D'Angelo, N, Whittington, D, Dussault, I. | | 登録日 | 2008-09-09 | | 公開日 | 2008-10-07 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Design, synthesis, and biological evaluation of potent c-Met inhibitors.
J.Med.Chem., 51, 2008
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3EFJ
 | | Structure of c-Met with pyrimidone inhibitor 7 | | 分子名称: | 2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methylpyrimidin-4(3H)-one, Hepatocyte growth factor receptor | | 著者 | D'Angelo, N, Bellon, S, Whittington, D. | | 登録日 | 2008-09-09 | | 公開日 | 2008-10-07 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Design, synthesis, and biological evaluation of potent c-Met inhibitors.
J.Med.Chem., 51, 2008
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7QK4
 | | EED in complex with PRC2 allosteric inhibitor compound 22 (MAK683) | | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | | 登録日 | 2021-12-17 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | | 主引用文献 | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022
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7QJG
 | | EED in complex with PRC2 allosteric inhibitor compound 6 | | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-7-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | | 登録日 | 2021-12-16 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022
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7QJU
 | | EED in complex with PRC2 allosteric inhibitor compound 7 | | 分子名称: | CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-[4-[(dimethylamino)methyl]phenyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C. | | 登録日 | 2021-12-17 | | 公開日 | 2022-04-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022
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8H03
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8H04
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8H05
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8HR2
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8VYG
 | | SARS-CoV-2 S RBD (C.37 Lambda variant) plus S309 Fab, local refinement | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S309 Heavy Chain, S309 Light Chain, ... | | 著者 | McCallum, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | 登録日 | 2024-02-08 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features.
Nat Commun, 15, 2024
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8VYE
 | | SARS-CoV-2 S (C.37 Lambda variant) plus S309, S2L20, and S2X303 Fabs | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S2L20 Heavy Chain, S2L20 Light Chain, ... | | 著者 | McCallum, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | 登録日 | 2024-02-08 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features.
Nat Commun, 15, 2024
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8VYF
 | | SARS-CoV-2 S NTD (C.37 Lambda variant) plus S2L20 and S2X303 Fabs, local refinement | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S2L20 Heavy Chain, ... | | 著者 | McCallum, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | 登録日 | 2024-02-08 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features.
Nat Commun, 15, 2024
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8T5C
 | | Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8.11G Heavy Chain, 8.11G Light Chain, ... | | 著者 | Gorman, J, Kwong, P.D. | | 登録日 | 2023-06-13 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability.
Nat Commun, 15, 2024
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5HYW
 | | The crystal structure of the D3-ASK1 complex | | 分子名称: | F-box/LRR-repeat MAX2 homolog, SKP1-like protein 1A | | 著者 | Yao, R.F, Ming, Z.H, Yan, L.M, Rao, Z.H, Lou, Z.Y, Xie, D.X. | | 登録日 | 2016-02-02 | | 公開日 | 2016-08-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | | 主引用文献 | DWARF14 is a non-canonical hormone receptor for strigolactone
Nature, 536, 2016
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7URC
 | | Human PORCN in complex with LGK974 | | 分子名称: | 2-[(2P)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-N-[(5P)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide, 2C11 heavy chain, 2C11 light chain, ... | | 著者 | Liu, Y, Qi, X, Li, X. | | 登録日 | 2022-04-21 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Nature, 607, 2022
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7URE
 | | Human PORCN in complex with palmitoleoylated WNT3A peptide | | 分子名称: | 2C11 heavy chain, 2C11 light chain, Digitonin, ... | | 著者 | Liu, Y, Qi, X, Li, X. | | 登録日 | 2022-04-21 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Nature, 607, 2022
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7URD
 | | Human PORCN in complex with LGK974 and WNT3A peptide | | 分子名称: | 2-[(2P)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-N-[(5P)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide, 2C11 heavy chain, 2C11 light chain, ... | | 著者 | Liu, Y, Qi, X, Li, X. | | 登録日 | 2022-04-21 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Nature, 607, 2022
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7URA
 | | Human PORCN in complex with Palmitoleoyl-CoA | | 分子名称: | 2C11 heavy chain, 2C11 light chain, CHOLESTEROL, ... | | 著者 | Liu, Y, Qi, X, Li, X. | | 登録日 | 2022-04-21 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Nature, 607, 2022
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7URF
 | | Human HHAT H379C in complex with SHH N-terminal peptide | | 分子名称: | 3H02 heavy chain, 3H02 light chain, Digitonin, ... | | 著者 | Liu, Y, Qi, X, Li, X. | | 登録日 | 2022-04-21 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Nature, 607, 2022
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