3EFJ

Structure of c-Met with pyrimidone inhibitor 7

Summary for 3EFJ

Related3EFK
DescriptorHepatocyte growth factor receptor, 2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methylpyrimidin-4(3H)-one (3 entities in total)
Functional Keywordsc-met, alternative splicing, atp-binding, chromosomal rearrangement, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, proto-oncogene, receptor, transferase, transmembrane, tyrosine-protein kinase
Biological sourceHomo sapiens (Human)
Cellular locationMembrane; Single-pass type I membrane protein P08581
Total number of polymer chains2
Total molecular weight71688.85
Authors
D'Angelo, N.,Bellon, S.,Whittington, D. (deposition date: 2008-09-09, release date: 2008-10-07, Last modification date: 2011-07-13)
Primary citation
D'Angelo, N.D.,Bellon, S.F.,Booker, S.K.,Cheng, Y.,Coxon, A.,Dominguez, C.,Fellows, I.,Hoffman, D.,Hungate, R.,Kaplan-Lefko, P.,Lee, M.R.,Li, C.,Liu, L.,Rainbeau, E.,Reider, P.J.,Rex, K.,Siegmund, A.,Sun, Y.,Tasker, A.S.,Xi, N.,Xu, S.,Yang, Y.,Zhang, Y.,Burgess, T.L.,Dussault, I.,Kim, T.S.
Design, synthesis, and biological evaluation of potent c-Met inhibitors.
J.Med.Chem., 51:5766-5779, 2008
PubMed: 18763753 (PDB entries with the same primary citation)
DOI: 10.1021/jm8006189
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers50.7%4.4%4.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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