3EFJ

Structure of c-Met with pyrimidone inhibitor 7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Hepatocyte growth factor receptor	polymer	310	35346.9	2	UniProt (P08581) Pfam (PF07714) In PDB	Homo sapiens (Human)	HGF receptor, Scatter factor receptor, SF receptor, HGF/SF receptor, Met proto-oncogene tyrosine kinase, c-Met
2	A, B	2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methylpyrimidin-4(3H)-one	non-polymer		497.5	2	Chemie (MT3)
3		water	water		18.0	82	Chemie (HOH)

Sequence modifications

A, B: 1048 - 1351 (UniProt: P08581)

PDB	External Database	Details
Met 1047	-	initiating methionine
Leu 1272	Val 1272	engineered mutation
His 1352	-	expression tag
His 1353	-	expression tag
His 1354	-	expression tag
His 1355	-	expression tag
His 1356	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70693.8
Non-Polymers*	Number of molecules	2
	Total formula weight	995.0
All*	Total formula weight	71688.9

*Water molecules are not included.