8C3N
 
 | |
8BR9
 | |
8C3J
 | | Stapled peptide SP2 in complex with humanised RadA mutant HumRadA22 | | Descriptor: | 2-[(4,6-diethyl-1,3,5-triazin-2-yl)-methyl-amino]ethanoic acid, Breast cancer type 2 susceptibility protein, DNA repair and recombination protein RadA | | Authors: | Pantelejevs, T, Hyvonen, M. | | Deposit date: | 2022-12-26 | | Release date: | 2023-11-29 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.02 Å) | | Cite: | A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase.
Chem Sci, 14, 2023
|
|
7QV8
 | |
7NUF
 | | Vaccinia virus protein 018 in complex with STAT1 | | Descriptor: | ACETYL GROUP, SULFATE ION, Signal transducer and activator of transcription 1-alpha/beta, ... | | Authors: | Pantelejevs, T, Talbot-Cooper, C, Smith, G.L, Hyvonen, M. | | Deposit date: | 2021-03-12 | | Release date: | 2021-07-28 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.0004015 Å) | | Cite: | Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling.
Cell Host Microbe, 30, 2022
|
|
6TUU
 | | Leishmania infantum Rad51 surrogate LiRadA10 in complex with 5,6,7,8-tetrahydro-2-naphthoic acid | | Descriptor: | 5,6,7,8-tetrahydronaphthalene-2-carboxylic acid, CHLORIDE ION, DNA repair and recombination protein RadA, ... | | Authors: | Pantelejevs, T, Hyvonen, M. | | Deposit date: | 2020-01-08 | | Release date: | 2021-01-27 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Development of dedicated crystallographic systems for structure-guided drug discovery
To Be Published
|
|
6Y4Q
 | | Structure of a stapled peptide bound to MDM2 | | Descriptor: | ACE-LEU-THR-PHE-GLY-GLU-TYR-TRP-ALA-GLN-LEU-ALA-SER, E3 ubiquitin-protein ligase Mdm2, ~{N}-[(1-ethyl-1,2,3-triazol-4-yl)methyl]-~{N},5-dimethyl-4-[2-[2-methyl-5-[methyl-[(1-propyl-1,2,3-triazol-4-yl)methyl]carbamoyl]thiophen-3-yl]cyclopenten-1-yl]thiophene-2-carboxamide | | Authors: | Pantelejevs, T, Bakanovych, I. | | Deposit date: | 2020-02-22 | | Release date: | 2020-05-20 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction.
Org.Biomol.Chem., 18, 2020
|
|
6HQU
 | | Humanised RadA mutant HumRadA22 in complex with a recombined BRC repeat 8-2 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Breast cancer type 2 susceptibility, DNA repair and recombination protein RadA, ... | | Authors: | Pantelejevs, T, Lindenburg, L, Hyvonen, M, Hollfelder, F. | | Deposit date: | 2018-09-25 | | Release date: | 2019-10-09 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats.
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
3Q1R
 | | Crystal structure of a bacterial RNase P holoenzyme in complex with TRNA and in the presence of 5' leader | | Descriptor: | MAGNESIUM ION, RNase P RNA, Ribonuclease P protein component, ... | | Authors: | Reiter, N.J, Ostermanm, A, Torres-Larios, A, Swinger, K.K, Pan, T, Mondragon, A. | | Deposit date: | 2010-12-17 | | Release date: | 2011-03-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (4.21 Å) | | Cite: | Structure of a Bacterial Ribonuclease P Holoenzyme in Complex with tRNA.
Nature, 468, 2010
|
|
3Q1Q
 | | Structure of a Bacterial Ribonuclease P Holoenzyme in Complex with tRNA | | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, RNase P RNA, ... | | Authors: | Reiter, N.J, Osterman, A, Torres-Larios, A, Swinger, K.K, Pan, T, Mondragon, A. | | Deposit date: | 2010-12-17 | | Release date: | 2011-03-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structure of a Bacterial Ribonuclease P Holoenzyme in Complex with tRNA.
Nature, 468, 2010
|
|
2A2E
 | | Crystal structure of the RNA subunit of Ribonuclease P. Bacterial A-type. | | Descriptor: | OSMIUM ION, RNA subunit of RNase P | | Authors: | Torres-Larios, A, Swinger, K.K, Krasilnikov, A.S, Pan, T, Mondragon, A. | | Deposit date: | 2005-06-22 | | Release date: | 2005-09-06 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.85 Å) | | Cite: | Crystal structure of the RNA component of bacterial ribonuclease P.
Nature, 437, 2005
|
|
1NBS
 | | Crystal structure of the specificity domain of Ribonuclease P RNA | | Descriptor: | LEAD (II) ION, MAGNESIUM ION, RIBONUCLEASE P RNA | | Authors: | Krasilnikov, A.S, Yang, X, Pan, T, Mondragon, A. | | Deposit date: | 2002-12-03 | | Release date: | 2003-02-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Crystal structure of the specificity domain of Ribonuclease P
Nature, 421, 2003
|
|
1U9S
 | | Crystal structure of the specificity domain of Ribonuclease P of the A-type | | Descriptor: | BARIUM ION, RIBONUCLEASE P | | Authors: | Krasilnikov, A.S, Xiao, Y, Pan, T, Mondragon, A. | | Deposit date: | 2004-08-10 | | Release date: | 2004-10-26 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Basis for structural diversity in homologous RNAs.
Science, 306, 2004
|
|
7ZWD
 | | Structure of SNAPc containing Pol II pre-initiation complex bound to U5 snRNA promoter (CC) | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. | | Deposit date: | 2022-05-19 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-28 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II.
Nat.Struct.Mol.Biol., 29, 2022
|
|
7ZX7
 | | Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (CC) | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. | | Deposit date: | 2022-05-20 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-28 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II.
Nat.Struct.Mol.Biol., 29, 2022
|
|
7ZXE
 | | Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (OC) | | Descriptor: | Non-template strand, TATA-box-binding protein, Template strand, ... | | Authors: | Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. | | Deposit date: | 2022-05-20 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-28 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II.
Nat.Struct.Mol.Biol., 29, 2022
|
|
7ZX8
 | | Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (OC) | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. | | Deposit date: | 2022-05-20 | | Release date: | 2022-12-07 | | Last modified: | 2022-12-28 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II.
Nat.Struct.Mol.Biol., 29, 2022
|
|
7ZWC
 | | Structure of SNAPc:TBP-TFIIA-TFIIB sub-complex bound to U5 snRNA promoter | | Descriptor: | Non-template strand, TATA-box-binding protein, Template strand, ... | | Authors: | Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. | | Deposit date: | 2022-05-19 | | Release date: | 2022-11-30 | | Last modified: | 2022-12-28 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II.
Nat.Struct.Mol.Biol., 29, 2022
|
|
5V47
 | | Crystal structure of the SR1 domain of lizard sacsin | | Descriptor: | Lizard sacsin, SULFATE ION | | Authors: | Pan, T, Menade, M, Kozlov, G, Gehring, K. | | Deposit date: | 2017-03-08 | | Release date: | 2017-05-24 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Structures of ubiquitin-like (Ubl) and Hsp90-like domains of sacsin provide insight into pathological mutations.
J. Biol. Chem., 293, 2018
|
|
5KNN
 | |
2LDZ
 | |
6O76
 | | Human cytosolic Histidyl-tRNA synthetase (HisRS) with WHEP domain | | Descriptor: | CHLORIDE ION, Histidine--tRNA ligase, cytoplasmic | | Authors: | Kuhle, B, Yang, X.L. | | Deposit date: | 2019-03-07 | | Release date: | 2019-09-11 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.787 Å) | | Cite: | CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells.
Proc.Natl.Acad.Sci.USA, 116, 2019
|
|
1LDZ
 | |
6JBH
 | | Cryo-EM structure and transport mechanism of a wall teichoic acid ABC transporter | | Descriptor: | TarG, TarH | | Authors: | Chen, L, Hou, W.T, Fan, T, Li, Y.H, Liu, B.H, Jiang, Y.L, Sun, L.F, Chen, Y, Zhou, C.Z. | | Deposit date: | 2019-01-25 | | Release date: | 2020-03-04 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.94 Å) | | Cite: | Cryo-electron Microscopy Structure and Transport Mechanism of a Wall Teichoic Acid ABC Transporter.
Mbio, 11, 2020
|
|
7MJR
 | | Vip4Da2 toxin structure | | Descriptor: | CALCIUM ION, SULFATE ION, Vip4Da1 protein | | Authors: | Rydel, T.J, Duda, D, Zheng, M, Henry, A. | | Deposit date: | 2021-04-20 | | Release date: | 2021-05-05 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.22 Å) | | Cite: | Structural and functional insights into the first Bacillus thuringiensis vegetative insecticidal protein of the Vpb4 fold, active against western corn rootworm.
Plos One, 16, 2021
|
|
