1U9S

Crystal structure of the specificity domain of Ribonuclease P of the A-type

Summary for 1U9S

Entry DOI	10.2210/pdb1u9s/pdb
Related	1NBS
Descriptor	RIBONUCLEASE P, BARIUM ION (2 entities in total)
Functional Keywords	rnase p, ribonuclease p rna, p rna, specificity domain, s-domain, ribozyme, trna, pre-trna, thermus thermophilus, rna
Total number of polymer chains	1
Total formula weight	55283.30
Authors	Krasilnikov, A.S.,Xiao, Y.,Pan, T.,Mondragon, A. (deposition date: 2004-08-10, release date: 2004-10-26, Last modification date: 2024-02-14)
Primary citation	Krasilnikov, A.S.,Xiao, Y.,Pan, T.,Mondragon, A. Basis for structural diversity in homologous RNAs. Science, 306:104-107, 2004 Cited by PubMed Abstract: Large RNA molecules, such as ribozymes, fold with well-defined tertiary structures that are important for their activity. There are many instances of ribozymes with identical function but differences in their secondary structures, suggesting alternative tertiary folds. Here, we report a crystal structure of the 161-nucleotide specificity domain of an A-type ribonuclease P that differs in secondary and tertiary structure from the specificity domain of a B-type molecule. Despite the differences, the cores of the domains have similar three-dimensional structure. Remarkably, the similar geometry of the cores is stabilized by a different set of interactions involving distinct auxiliary elements. PubMed: 15459389 DOI: 10.1126/science.1101489 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation