6HQU
Humanised RadA mutant HumRadA22 in complex with a recombined BRC repeat 8-2
Summary for 6HQU
Entry DOI | 10.2210/pdb6hqu/pdb |
Descriptor | DNA repair and recombination protein RadA, Breast cancer type 2 susceptibility, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | rada, rad51, brc repeat, recombinase, atpase, brca2, oncoprotein |
Biological source | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) More |
Total number of polymer chains | 15 |
Total formula weight | 235811.60 |
Authors | Pantelejevs, T.,Lindenburg, L.,Hyvonen, M.,Hollfelder, F. (deposition date: 2018-09-25, release date: 2019-10-09, Last modification date: 2024-02-07) |
Primary citation | Lindenburg, L.H.,Pantelejevs, T.,Gielen, F.,Zuazua-Villar, P.,Butz, M.,Rees, E.,Kaminski, C.F.,Downs, J.A.,Hyvonen, M.,Hollfelder, F. Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34772801DOI: 10.1073/pnas.2017708118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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