6HQU

Humanised RadA mutant HumRadA22 in complex with a recombined BRC repeat 8-2

Summary for 6HQU

• Entry DOI: 10.2210/pdb6hqu/pdb
• Descriptor: DNA repair and recombination protein RadA, Breast cancer type 2 susceptibility, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: rada, rad51, brc repeat, recombinase, atpase, brca2, oncoprotein
• Biological source: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1); More
• Total number of polymer chains: 15
• Total formula weight: 235811.60

Authors

Pantelejevs, T.,Lindenburg, L.,Hyvonen, M.,Hollfelder, F. (deposition date: 2018-09-25, release date: 2019-10-09, Last modification date: 2024-02-07)

• Primary citation: Lindenburg, L.H.,Pantelejevs, T.,Gielen, F.,Zuazua-Villar, P.,Butz, M.,Rees, E.,Kaminski, C.F.,Downs, J.A.,Hyvonen, M.,Hollfelder, F.; Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34772801; DOI: 10.1073/pnas.2017708118

Experimental method

X-RAY DIFFRACTION (1.97 Å)