Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HQU

Humanised RadA mutant HumRadA22 in complex with a recombined BRC repeat 8-2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006281	biological_process	DNA repair
A	0006310	biological_process	DNA recombination
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0016887	molecular_function	ATP hydrolysis activity
A	0140664	molecular_function	ATP-dependent DNA damage sensor activity
B	0003677	molecular_function	DNA binding
B	0003684	molecular_function	damaged DNA binding
B	0005524	molecular_function	ATP binding
B	0006259	biological_process	DNA metabolic process
B	0006281	biological_process	DNA repair
B	0006310	biological_process	DNA recombination
B	0008094	molecular_function	ATP-dependent activity, acting on DNA
B	0016887	molecular_function	ATP hydrolysis activity
B	0140664	molecular_function	ATP-dependent DNA damage sensor activity
C	0003677	molecular_function	DNA binding
C	0003684	molecular_function	damaged DNA binding
C	0005524	molecular_function	ATP binding
C	0006259	biological_process	DNA metabolic process
C	0006281	biological_process	DNA repair
C	0006310	biological_process	DNA recombination
C	0008094	molecular_function	ATP-dependent activity, acting on DNA
C	0016887	molecular_function	ATP hydrolysis activity
C	0140664	molecular_function	ATP-dependent DNA damage sensor activity
D	0003677	molecular_function	DNA binding
D	0003684	molecular_function	damaged DNA binding
D	0005524	molecular_function	ATP binding
D	0006259	biological_process	DNA metabolic process
D	0006281	biological_process	DNA repair
D	0006310	biological_process	DNA recombination
D	0008094	molecular_function	ATP-dependent activity, acting on DNA
D	0016887	molecular_function	ATP hydrolysis activity
D	0140664	molecular_function	ATP-dependent DNA damage sensor activity
E	0003677	molecular_function	DNA binding
E	0003684	molecular_function	damaged DNA binding
E	0005524	molecular_function	ATP binding
E	0006259	biological_process	DNA metabolic process
E	0006281	biological_process	DNA repair
E	0006310	biological_process	DNA recombination
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0016887	molecular_function	ATP hydrolysis activity
E	0140664	molecular_function	ATP-dependent DNA damage sensor activity
F	0003677	molecular_function	DNA binding
F	0003684	molecular_function	damaged DNA binding
F	0005524	molecular_function	ATP binding
F	0006259	biological_process	DNA metabolic process
F	0006281	biological_process	DNA repair
F	0006310	biological_process	DNA recombination
F	0008094	molecular_function	ATP-dependent activity, acting on DNA
F	0016887	molecular_function	ATP hydrolysis activity
F	0140664	molecular_function	ATP-dependent DNA damage sensor activity
G	0003677	molecular_function	DNA binding
G	0003684	molecular_function	damaged DNA binding
G	0005524	molecular_function	ATP binding
G	0006259	biological_process	DNA metabolic process
G	0006281	biological_process	DNA repair
G	0006310	biological_process	DNA recombination
G	0008094	molecular_function	ATP-dependent activity, acting on DNA
G	0016887	molecular_function	ATP hydrolysis activity
G	0140664	molecular_function	ATP-dependent DNA damage sensor activity
H	0003677	molecular_function	DNA binding
H	0003684	molecular_function	damaged DNA binding
H	0005524	molecular_function	ATP binding
H	0006259	biological_process	DNA metabolic process
H	0006281	biological_process	DNA repair
H	0006310	biological_process	DNA recombination
H	0008094	molecular_function	ATP-dependent activity, acting on DNA
H	0016887	molecular_function	ATP hydrolysis activity
H	0140664	molecular_function	ATP-dependent DNA damage sensor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue ADP A 401

Chain	Residue
A	GLU139
A	ARG323
A	ILE342
A	MG402
A	HOH502
A	HOH504
A	HOH509
A	HOH534
C	GLU184
C	GLU344
C	ADP401
A	GLY141
A	SER142
A	GLY143
A	LYS144
A	THR145
A	GLN146
A	ARG181
A	GLU184

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 402

Chain	Residue
A	THR145
A	ADP401
A	HOH501
A	HOH502
A	HOH504
A	HOH532

site_id	AC3
Number of Residues	15
Details	binding site for residue ADP B 401

Chain	Residue
B	PHE140
B	GLY141
B	SER142
B	GLY143
B	LYS144
B	THR145
B	GLN146
B	ARG181
B	ARG323
B	ILE342
B	MG402
B	HOH520
B	HOH521
B	HOH525
B	HOH526

site_id	AC4
Number of Residues	6
Details	binding site for residue MG B 402

Chain	Residue
B	THR145
B	ADP401
B	HOH506
B	HOH520
B	HOH525
B	HOH526

site_id	AC5
Number of Residues	20
Details	binding site for residue ADP C 401

Chain	Residue
A	GLU344
A	ADP401
C	GLU139
C	GLY141
C	SER142
C	GLY143
C	LYS144
C	THR145
C	GLN146
C	ARG181
C	GLU184
C	ARG323
C	ILE342
C	THR343
C	MG402
C	HOH505
C	HOH507
C	HOH515
C	HOH519
C	HOH522

site_id	AC6
Number of Residues	6
Details	binding site for residue MG C 402

Chain	Residue
C	THR145
C	ADP401
C	HOH501
C	HOH505
C	HOH507
C	HOH515

site_id	AC7
Number of Residues	16
Details	binding site for residue ADP D 401

Chain	Residue
D	GLU139
D	PHE140
D	GLY141
D	SER142
D	GLY143
D	LYS144
D	THR145
D	GLN146
D	ARG181
D	ARG323
D	ILE342
D	MG402
D	HOH505
D	HOH506
D	HOH510
D	HOH527

site_id	AC8
Number of Residues	6
Details	binding site for residue MG D 402

Chain	Residue
D	THR145
D	ADP401
D	HOH504
D	HOH505
D	HOH510
D	HOH512

site_id	AC9
Number of Residues	17
Details	binding site for residue ADP E 401

Chain	Residue
E	LYS144
E	THR145
E	GLN146
E	ARG181
E	GLU184
E	ARG323
E	ILE342
E	MG402
E	HOH502
E	HOH506
E	HOH517
E	HOH521
E	GLU139
E	PHE140
E	GLY141
E	SER142
E	GLY143

site_id	AD1
Number of Residues	6
Details	binding site for residue MG E 402

Chain	Residue
E	THR145
E	ADP401
E	HOH502
E	HOH512
E	HOH514
E	HOH517

site_id	AD2
Number of Residues	12
Details	binding site for residue ADP F 401

Chain	Residue
F	GLU139
F	GLY141
F	SER142
F	GLY143
F	LYS144
F	THR145
F	GLN146
F	ARG181
F	GLU184
F	ARG323
F	ILE342
F	MG402

site_id	AD3
Number of Residues	2
Details	binding site for residue MG F 402

Chain	Residue
F	THR145
F	ADP401

site_id	AD4
Number of Residues	13
Details	binding site for residue ADP G 401

Chain	Residue
G	GLU139
G	GLY141
G	SER142
G	GLY143
G	LYS144
G	THR145
G	GLN146
G	ARG181
G	GLU184
G	ARG323
G	ILE342
G	MG402
G	HOH504

site_id	AD5
Number of Residues	3
Details	binding site for residue MG G 402

Chain	Residue
G	THR145
G	ADP401
G	HOH504

site_id	AD6
Number of Residues	12
Details	binding site for residue ADP H 401

Chain	Residue
H	GLU139
H	PHE140
H	GLY141
H	SER142
H	GLY143
H	LYS144
H	THR145
H	GLN146
H	ARG181
H	ARG323
H	ILE342
H	MG402

site_id	AD7
Number of Residues	2
Details	binding site for residue MG H 402

Chain	Residue
H	THR145
H	ADP401

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)