8C3N

Stapled peptide SP30 in complex with humanised RadA mutant HumRadA22

Summary for 8C3N

Entry DOI	10.2210/pdb8c3n/pdb
Descriptor	DNA repair and recombination protein RadA, Breast cancer type 2 susceptibility protein, ADENOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywords	stapled peptide, rad51, brca2, brc repeat, recombination
Biological source	Pyrococcus furiosus More
Total number of polymer chains	2
Total formula weight	29054.12
Authors	Pantelejevs, T.,Hyvonen, M. (deposition date: 2022-12-27, release date: 2023-03-08, Last modification date: 2023-12-27)
Primary citation	Pantelejevs, T.,Zuazua-Villar, P.,Koczy, O.,Counsell, A.J.,Walsh, S.J.,Robertson, N.S.,Spring, D.R.,Downs, J.A.,Hyvonen, M. A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase. Chem Sci, 14:13915-13923, 2023 Cited by PubMed: 38075664 DOI: 10.1039/d3sc03331g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.21 Å)

Structure validation