5A5G
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![BU of 5a5g by Molmil](/molmil-images/mine/5a5g) | Crystal structure of FTHFS2 from T.acetoxydans Re1 | Descriptor: | DI(HYDROXYETHYL)ETHER, FORMATE--TETRAHYDROFOLATE LIGASE, GLYCEROL, ... | Authors: | Bergdahl, R, Jacobson, F, Muller, B, Mikkelsen, N, Schurer, A, Sandgren, M. | Deposit date: | 2015-06-17 | Release date: | 2016-07-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Characterization, Crystallization and Three- Dimensional Structures of Formyltetrahydrofolate Synthetase (Fthfs) from the Syntrophic Acetate Oxidising Bacterium Tepidanaerobacter Acetatoxydans Re1 To be Published
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1KKS
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![BU of 1kks by Molmil](/molmil-images/mine/1kks) | Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression | Descriptor: | 5'-R(*GP*GP*AP*AP*GP*GP*CP*CP*CP*UP*UP*UP*UP*CP*AP*GP*GP*GP*CP*CP*AP*CP*CP*C)-3' | Authors: | Zanier, K, Luyten, I, Crombie, C, Muller, B, Schuemperli, D, Linge, J.P, Nilges, M, Sattler, M. | Deposit date: | 2001-12-10 | Release date: | 2002-03-13 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression. RNA, 8, 2002
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5A4J
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![BU of 5a4j by Molmil](/molmil-images/mine/5a4j) | Crystal structure of FTHFS1 from T.acetoxydans Re1 | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, D(-)-TARTARIC ACID, ... | Authors: | Bergdahl, R, Jacobson, F, Muller, B, Mikkelsen, N, Schurer, A, Sandgren, M. | Deposit date: | 2015-06-10 | Release date: | 2016-07-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Characterization, Crystallization and Three- Dimensional Structures of Formyltetrahydrofolate Synthetase (Fthfs) from the Syntrophic Acetate Oxidising Bacterium Tepidanaerobacter Acetatoxydans Re1 To be Published
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7TBM
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![BU of 7tbm by Molmil](/molmil-images/mine/7tbm) | Composite structure of the dilated human nuclear pore complex (NPC) generated with a 37A in situ cryo-ET map of CD4+ T cell NPC | Descriptor: | DDX19, NUP107 CTD, NUP107 NTD, ... | Authors: | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | Deposit date: | 2021-12-22 | Release date: | 2022-06-15 | Last modified: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (37 Å) | Cite: | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7TBK
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![BU of 7tbk by Molmil](/molmil-images/mine/7tbk) | Composite structure of the dilated human nuclear pore complex (NPC) symmetric core generated with a 37A in situ cryo-ET map of CD4+ T cell NPC | Descriptor: | NUP107 CTD, NUP107 NTD, NUP133, ... | Authors: | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | Deposit date: | 2021-12-22 | Release date: | 2022-06-15 | Last modified: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (37 Å) | Cite: | Architecture of the linker-scaffold in the nuclear pore. Science, 376, 2022
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7OVR
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![BU of 7ovr by Molmil](/molmil-images/mine/7ovr) | Mature HIV-1 matrix structure | Descriptor: | HIV-1 matrix, MYRISTIC ACID, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Qu, K, Ke, Z.L, Zila, V, Anders-Oesswein, M, Glass, B, Muecksch, F, Mueller, R, Schultz, C, Mueller, B, Kraeusslich, H.G, Briggs, J.A.G. | Deposit date: | 2021-06-15 | Release date: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Maturation of the matrix and viral membrane of HIV-1. Science, 373, 2021
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7OVQ
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![BU of 7ovq by Molmil](/molmil-images/mine/7ovq) | Immature HIV-1 matrix structure | Descriptor: | Gag polyprotein, MYRISTIC ACID | Authors: | Qu, K, Ke, Z.L, Zila, V, Anders-Oesswein, M, Glass, B, Muecksch, F, Mueller, R, Schultz, C, Mueller, B, Kraeusslich, H.G, Briggs, J.A.G. | Deposit date: | 2021-06-15 | Release date: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (7.2 Å) | Cite: | Maturation of the matrix and viral membrane of HIV-1. Science, 373, 2021
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4USN
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![BU of 4usn by Molmil](/molmil-images/mine/4usn) | The structure of the immature HIV-1 capsid in intact virus particles at sub-nm resolution | Descriptor: | P24 | Authors: | Schur, F.K.M, Hagen, W.J.H, Rumlova, M, Ruml, T, Mueller, B, Kraeusslich, H.-G, Briggs, J.A.G. | Deposit date: | 2014-07-11 | Release date: | 2014-11-05 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (8.8 Å) | Cite: | Structure of the Immature HIV-1 Capsid in Intact Virus Particles at 8.8 A Resolution. Nature, 517, 2015
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4U7Q
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![BU of 4u7q by Molmil](/molmil-images/mine/4u7q) | Structure of wild-type HIV protease in complex with photosensitive inhibitor PDI-6 | Descriptor: | N~2~-({[7-(diethylamino)-2-oxo-2H-chromen-4-yl]methoxy}carbonyl)-N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-L-valinamide, V-1 protease | Authors: | Pachl, P, Rezacova, P, Schimer, J. | Deposit date: | 2014-07-31 | Release date: | 2015-03-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor. Nat Commun, 6, 2015
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4U7V
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![BU of 4u7v by Molmil](/molmil-images/mine/4u7v) | Structure of wild-type HIV protease in complex with degraded photosensitive inhibitor | Descriptor: | BETA-MERCAPTOETHANOL, N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-L-valinamide, V-1 protease | Authors: | Pachl, P, Rezacova, P, Schimer, J. | Deposit date: | 2014-07-31 | Release date: | 2015-03-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.38 Å) | Cite: | Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor. Nat Commun, 6, 2015
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1N64
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![BU of 1n64 by Molmil](/molmil-images/mine/1n64) | Crystal structure analysis of the immunodominant antigenic site on Hepatitis C virus protein bound to mAb 19D9D6 | Descriptor: | Fab 19D9D6 heavy chain, Fab 19D9D6 light chain, Genome polyprotein Capsid protein C | Authors: | Menez, R, Bossus, M, Muller, B, Sibai, G, Dalbon, P, Ducancel, F, Jolivet-Reynaud, C, Stura, E. | Deposit date: | 2002-11-08 | Release date: | 2003-02-25 | Last modified: | 2013-09-18 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Crystal structure of a hydrophobic immunodominant
antigenic site on hepatitis C virus core protein
complexed to monoclonal antibody 19D9D6. J.Immunol., 170, 2003
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1NLB
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![BU of 1nlb by Molmil](/molmil-images/mine/1nlb) | crystal structure of anti-HCV monoclonal antibody 19D9D6 | Descriptor: | antibody 19D9D6 heavy chain, antibody 19D9D6 light chain | Authors: | Menez, R, Bossus, M, Muller, B, Sibai, G, Dalbon, P, Ducancel, F, Jolivet-Reynaud, C, Stura, E. | Deposit date: | 2003-01-07 | Release date: | 2003-02-25 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of a hydrophobic immunodominant
antigenic site on hepatitis C virus core protein
complexed to monoclonal antibody 19D9D6. J.Immunol., 170, 2003
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3WQS
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![BU of 3wqs by Molmil](/molmil-images/mine/3wqs) | Crystal structure of pfdxr complexed with inhibitor-126 | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, MAGNESIUM ION, ... | Authors: | Tanaka, N, Umeda, T. | Deposit date: | 2014-01-31 | Release date: | 2014-11-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC. J.Med.Chem., 57, 2014
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8FG0
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![BU of 8fg0 by Molmil](/molmil-images/mine/8fg0) | |
4KP7
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![BU of 4kp7 by Molmil](/molmil-images/mine/4kp7) | Structure of Plasmodium IspC in complex with a beta-thia-isostere derivative of Fosmidomycin | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, MANGANESE (III) ION, ... | Authors: | Kunfermann, A, Bacher, A, Groll, M. | Deposit date: | 2013-05-13 | Release date: | 2013-10-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | IspC as Target for Antiinfective Drug Discovery: Synthesis, Enantiomeric Separation, and Structural Biology of Fosmidomycin Thia Isosters. J.Med.Chem., 56, 2013
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3WQR
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![BU of 3wqr by Molmil](/molmil-images/mine/3wqr) | Crystal structure of pfdxr complexed with inhibitor-12 | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, CALCIUM ION, ... | Authors: | Tanaka, N, Umeda, T. | Deposit date: | 2014-01-31 | Release date: | 2014-11-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC. J.Med.Chem., 57, 2014
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3WQQ
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![BU of 3wqq by Molmil](/molmil-images/mine/3wqq) | Crystal structure of PfDXR complexed with inhibitor-3 | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, CALCIUM ION, ... | Authors: | Tanaka, N, Umeda, T. | Deposit date: | 2014-01-31 | Release date: | 2014-11-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC. J.Med.Chem., 57, 2014
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6AZM
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![BU of 6azm by Molmil](/molmil-images/mine/6azm) | Crystal structure of the 580 germline antibody bound to circumsporozoite protein NANP 5-mer | Descriptor: | 580 germline antibody, heavy chain, light chain, ... | Authors: | Scally, S.W, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | Deposit date: | 2017-09-11 | Release date: | 2017-12-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies. Immunity, 47, 2017
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6B0S
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![BU of 6b0s by Molmil](/molmil-images/mine/6b0s) | Crystal structure of circumsporozoite protein aTSR domain in complex with 1710 antibody | Descriptor: | 1710 antibody, heavy chain, light chain, ... | Authors: | Scally, S.W, Murugan, R, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | Deposit date: | 2017-09-15 | Release date: | 2017-11-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection. J. Exp. Med., 215, 2018
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6AZX
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![BU of 6azx by Molmil](/molmil-images/mine/6azx) | Crystal structure of the neutralizing anti-circumsporozoite protein 663 antibody | Descriptor: | 663 antibody, heavy chain, light chain | Authors: | Scally, S.W, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | Deposit date: | 2017-09-13 | Release date: | 2017-12-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies. Immunity, 47, 2017
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6B0W
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![BU of 6b0w by Molmil](/molmil-images/mine/6b0w) | Crystal structure of the anti-circumsporozoite protein 1710 antibody | Descriptor: | 1710 antibody, heavy chain, light chain, ... | Authors: | Scally, S.W, Murugan, R, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | Deposit date: | 2017-09-15 | Release date: | 2017-11-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection. J. Exp. Med., 215, 2018
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6D0X
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![BU of 6d0x by Molmil](/molmil-images/mine/6d0x) | Crystal structure of chimeric H.2140 / K.1210 Fab in complex with circumsporozoite protein NANP3 | Descriptor: | 1210 Antibody, light chain, 2140 Antibody, ... | Authors: | Scally, S.W, Bosch, A, Imkeller, K, Wardemann, H, Julien, J.P. | Deposit date: | 2018-04-11 | Release date: | 2018-06-13 | Last modified: | 2018-07-04 | Method: | X-RAY DIFFRACTION (1.849 Å) | Cite: | Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope. Science, 360, 2018
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6D01
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![BU of 6d01 by Molmil](/molmil-images/mine/6d01) | Crystal structure of 1210 Fab in complex with circumsporozoite protein NANP5 | Descriptor: | 1,2-ETHANEDIOL, 1210 Antibody, Light chain, ... | Authors: | Scally, S.W, Bosch, A, Imkeller, K, Wardemann, H, Julien, J.P. | Deposit date: | 2018-04-09 | Release date: | 2018-06-13 | Last modified: | 2018-07-04 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope. Science, 360, 2018
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6D11
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![BU of 6d11 by Molmil](/molmil-images/mine/6d11) | Crystal structure of 1450 Fab in complex with circumsporozoite protein NANP5 | Descriptor: | 1450 Antibody, Heavy chain, Light chain, ... | Authors: | Scally, S.W, Bosch, A, Imkeller, K, Wardemann, H, Julien, J.P. | Deposit date: | 2018-04-11 | Release date: | 2018-06-13 | Last modified: | 2018-07-04 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope. Science, 360, 2018
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5BK5
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![BU of 5bk5 by Molmil](/molmil-images/mine/5bk5) | Crystal structure of the anti-circumsporozoite protein 663 germline antibody | Descriptor: | 663 germline antibody, heavy chain, light chain, ... | Authors: | Scally, S.W, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | Deposit date: | 2017-09-12 | Release date: | 2017-12-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies. Immunity, 47, 2017
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