7OVR
Mature HIV-1 matrix structure
Summary for 7OVR
| Entry DOI | 10.2210/pdb7ovr/pdb |
| EMDB information | 13079 13088 |
| Descriptor | HIV-1 matrix, MYRISTIC ACID, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (3 entities in total) |
| Functional Keywords | hiv-1, gag, matrix, virus |
| Biological source | Human immunodeficiency virus 1 |
| Total number of polymer chains | 24 |
| Total formula weight | 337438.08 |
| Authors | Qu, K.,Ke, Z.L.,Zila, V.,Anders-Oesswein, M.,Glass, B.,Muecksch, F.,Mueller, R.,Schultz, C.,Mueller, B.,Kraeusslich, H.G.,Briggs, J.A.G. (deposition date: 2021-06-15, release date: 2021-08-18, Last modification date: 2024-11-13) |
| Primary citation | Qu, K.,Ke, Z.,Zila, V.,Anders-Osswein, M.,Glass, B.,Mucksch, F.,Muller, R.,Schultz, C.,Muller, B.,Krausslich, H.G.,Briggs, J.A.G. Maturation of the matrix and viral membrane of HIV-1. Science, 373:700-704, 2021 Cited by PubMed Abstract: Gag, the primary structural protein of HIV-1, is recruited to the plasma membrane for virus assembly by its matrix (MA) domain. Gag is subsequently cleaved into its component domains, causing structural maturation to repurpose the virion for cell entry. We determined the structure and arrangement of MA within immature and mature HIV-1 through cryo-electron tomography. We found that MA rearranges between two different hexameric lattices upon maturation. In mature HIV-1, a lipid extends out of the membrane to bind with a pocket in MA. Our data suggest that proteolytic maturation of HIV-1 not only assembles the viral capsid surrounding the genome but also repurposes the membrane-bound MA lattice for an entry or postentry function and results in the partial removal of up to 2500 lipids from the viral membrane. PubMed: 34353956DOI: 10.1126/science.abe6821 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (7 Å) |
Structure validation
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