3WQS

Crystal structure of pfdxr complexed with inhibitor-126

Summary for 3WQS

Entry DOI	10.2210/pdb3wqs/pdb
Related	3WQQ 3WQR
Descriptor	1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	reductoisomerase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Plasmodium falciparum
Cellular location	Plastid, apicoplast : O96693
Total number of polymer chains	1
Total formula weight	56904.56
Authors	Tanaka, N.,Umeda, T. (deposition date: 2014-01-31, release date: 2014-11-26, Last modification date: 2024-03-20)
Primary citation	Konzuch, S.,Umeda, T.,Held, J.,Hahn, S.,Brucher, K.,Lienau, C.,Behrendt, C.T.,Grawert, T.,Bacher, A.,Illarionov, B.,Fischer, M.,Mordmuller, B.,Tanaka, N.,Kurz, T. Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC. J.Med.Chem., 57:8827-8838, 2014 Cited by PubMed: 25254502 DOI: 10.1021/jm500850y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation