4U7V

Structure of wild-type HIV protease in complex with degraded photosensitive inhibitor

Summary for 4U7V

• Entry DOI: 10.2210/pdb4u7v/pdb
• Related: 4U7Q
• Descriptor: V-1 protease, BETA-MERCAPTOETHANOL, N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-L-valinamide, ... (4 entities in total)
• Functional Keywords: hiv-1, viral protease, aspartic protease, inhibition, hydrolase
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22290.56

Authors

Pachl, P.,Rezacova, P.,Schimer, J. (deposition date: 2014-07-31, release date: 2015-03-25, Last modification date: 2023-12-20)

• Primary citation: Schimer, J.,Pavova, M.,Anders, M.,Pachl, P.,Sacha, P.,Cigler, P.,Weber, J.,Majer, P.,Rezacova, P.,Krausslich, H.G.,Muller, B.,Konvalinka, J.; Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor.; Nat Commun, 6:6461-6461, 2015; PubMed: 25751579; DOI: 10.1038/ncomms7461

Experimental method

X-RAY DIFFRACTION (1.38 Å)