3WQQ
Crystal structure of PfDXR complexed with inhibitor-3
Summary for 3WQQ
| Entry DOI | 10.2210/pdb3wqq/pdb |
| Related | 3WQR 3WQS |
| Descriptor | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, MAGNESIUM ION, ... (6 entities in total) |
| Functional Keywords | reductoisomerase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Plasmodium falciparum |
| Cellular location | Plastid, apicoplast : O96693 |
| Total number of polymer chains | 2 |
| Total formula weight | 113853.32 |
| Authors | Tanaka, N.,Umeda, T. (deposition date: 2014-01-31, release date: 2014-11-26, Last modification date: 2024-03-20) |
| Primary citation | Konzuch, S.,Umeda, T.,Held, J.,Hahn, S.,Brucher, K.,Lienau, C.,Behrendt, C.T.,Grawert, T.,Bacher, A.,Illarionov, B.,Fischer, M.,Mordmuller, B.,Tanaka, N.,Kurz, T. Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC. J.Med.Chem., 57:8827-8838, 2014 Cited by PubMed: 25254502DOI: 10.1021/jm500850y PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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