4GQ4
| Human menin with bound inhibitor MI-2-2 | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine, ... | Authors: | Shi, A, Murai, M.J, He, S, Lund, G.L, Hartley, T, Purohit, T, Reddy, G, Chruszcz, M, Grembecka, J, Cierpicki, T. | Deposit date: | 2012-08-22 | Release date: | 2012-09-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood, 120, 2012
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7CXM
| Architecture of a SARS-CoV-2 mini replication and transcription complex | Descriptor: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | Authors: | Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | Deposit date: | 2020-09-02 | Release date: | 2020-11-04 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Architecture of a SARS-CoV-2 mini replication and transcription complex. Nat Commun, 11, 2020
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7D1A
| cryo-EM structure of a group II intron RNP complexed with its reverse transcriptase | Descriptor: | Group II intron-encoded protein LtrA, RNA (5'-R(P*CP*AP*CP*AP*UP*CP*CP*AP*UP*AP*AP*C)-3'), RNA (692-MER) | Authors: | Liu, N, Dong, X.L, Hu, C.X, Zeng, J.W, Wang, J.W, Wang, J, Wang, H.W, Belfort, M. | Deposit date: | 2020-09-14 | Release date: | 2020-10-21 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing. Nucleic Acids Res., 48, 2020
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7CY8
| Crystal Structure of CMD1 in complex with 5mC-DNA and vitamin C | Descriptor: | 1,2-ETHANEDIOL, ASCORBIC ACID, DNA (5'-D(P*(5CM)P*GP*CP*GP*CP*GP*GP*GP*A)-3'), ... | Authors: | Li, W, Zhang, T, Sun, M, Ding, J. | Deposit date: | 2020-09-03 | Release date: | 2020-12-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular mechanism for vitamin C-derived C 5 -glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1. Nat Commun, 12, 2021
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8VYE
| SARS-CoV-2 S (C.37 Lambda variant) plus S309, S2L20, and S2X303 Fabs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S2L20 Heavy Chain, S2L20 Light Chain, ... | Authors: | McCallum, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2024-02-08 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features. Nat Commun, 15, 2024
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7CY4
| Crystal Structure of CMD1 in apo form | Descriptor: | CITRIC ACID, FE (III) ION, Maltodextrin-binding protein,5-methylcytosine-modifying enzyme 1 | Authors: | Li, W, Zhang, T, Sun, M, Ding, J. | Deposit date: | 2020-09-03 | Release date: | 2020-12-30 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Molecular mechanism for vitamin C-derived C 5 -glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1. Nat Commun, 12, 2021
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8VYF
| SARS-CoV-2 S NTD (C.37 Lambda variant) plus S2L20 and S2X303 Fabs, local refinement | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S2L20 Heavy Chain, ... | Authors: | McCallum, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2024-02-08 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features. Nat Commun, 15, 2024
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8VYG
| SARS-CoV-2 S RBD (C.37 Lambda variant) plus S309 Fab, local refinement | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S309 Heavy Chain, S309 Light Chain, ... | Authors: | McCallum, M, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2024-02-08 | Release date: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features. Nat Commun, 15, 2024
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7DHY
| Arsenic-bound p53 DNA-binding domain mutant G245S | Descriptor: | ARSENIC, Cellular tumor antigen p53, GLYCEROL, ... | Authors: | Chen, S, Lu, M. | Deposit date: | 2020-11-18 | Release date: | 2021-03-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site. Cancer Cell, 39, 2021
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7DHZ
| Arsenic-bound p53 DNA-binding domain mutant R249S | Descriptor: | ARSENIC, Cellular tumor antigen p53, GLYCEROL, ... | Authors: | Chen, S, Lu, M. | Deposit date: | 2020-11-18 | Release date: | 2021-03-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site. Cancer Cell, 39, 2021
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7D5J
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7D98
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7DCZ
| Crystal Structure of BACE1 in complex with N-{3-[(4S)-2-amino-4-methyl-4H-1,3-thiazin-4-yl]-4- fluorophenyl}-5-cyanopyridine-2-carboxamide | Descriptor: | Beta-secretase 1, GLYCEROL, IODIDE ION, ... | Authors: | Koriyama, Y, Hori, A, Ito, H, Yonezawa, S, Baba, Y, Tanimoto, N, Ueno, T, Yamamoto, S, Yamamoto, T, Asada, N, Morimoto, K, Einaru, S, Sakai, K, Kanazu, T, Matsuda, A, Yamaguchi, Y, Oguma, T, Timmers, M, Tritsmans, L, Kusakabe, K.I, Kato, A, Sakaguchi, G. | Deposit date: | 2020-10-27 | Release date: | 2021-03-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based beta-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial. J.Med.Chem., 64, 2021
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4UON
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7DOP
| Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1 | Descriptor: | Nonstructural Protein 1, ZINC ION | Authors: | Zhang, K, Law, Y.S, Law, M.C.Y, Tan, Y.B, Wirawan, M, Luo, D.H. | Deposit date: | 2020-12-15 | Release date: | 2021-03-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.38 Å) | Cite: | Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1. Cell Host Microbe, 29, 2021
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7D4P
| Structure of human TRPC5 in complex with clemizole | Descriptor: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole, ... | Authors: | Chen, L, Song, K, Wei, M, Guo, W. | Deposit date: | 2020-09-24 | Release date: | 2021-03-31 | Last modified: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021
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7D4Q
| Structure of human TRPC5 in complex with HC-070 | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione, CALCIUM ION, ... | Authors: | Chen, L, Song, K, Wei, M, Guo, W. | Deposit date: | 2020-09-24 | Release date: | 2021-03-31 | Last modified: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021
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7D2G
| Coiled-coil structure of liprin-alpha2_H2delC | Descriptor: | GLYCEROL, Liprin-alpha-2 | Authors: | Liang, M, Wei, Z. | Deposit date: | 2020-09-16 | Release date: | 2021-04-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Oligomerized liprin-alpha promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. Cell Rep, 34, 2021
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7D2E
| Tetrameric coiled-coil structure of liprin-alpha2_H3 | Descriptor: | Liprin-alpha-2 | Authors: | Liang, M, Wei, Z. | Deposit date: | 2020-09-16 | Release date: | 2021-04-07 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Oligomerized liprin-alpha promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. Cell Rep, 34, 2021
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7D2H
| Tetrameric coiled-coil structure of liprin-alpha2_H2 | Descriptor: | GLYCEROL, Liprin-alpha-2 | Authors: | Liang, M, Wei, Z. | Deposit date: | 2020-09-16 | Release date: | 2021-04-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Oligomerized liprin-alpha promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. Cell Rep, 34, 2021
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7D10
| Human NKCC1 | Descriptor: | PALMITIC ACID, Solute carrier family 12 member 2 | Authors: | Zhang, S, Yang, M. | Deposit date: | 2020-09-12 | Release date: | 2021-04-14 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2. Commun Biol, 4, 2021
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7D14
| Mouse KCC2 | Descriptor: | Solute carrier family 12 member 5 | Authors: | Zhang, S, Yang, M. | Deposit date: | 2020-09-13 | Release date: | 2021-04-14 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2. Commun Biol, 4, 2021
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7DHG
| Crystal structure of SARS-CoV-2 Orf9b complex with human TOM70 | Descriptor: | Mitochondrial import receptor subunit TOM70, ORF9b protein | Authors: | Gao, X, Zhu, K, Qin, B, Olieric, V, Wang, M, Cui, S. | Deposit date: | 2020-11-14 | Release date: | 2021-05-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions. Nat Commun, 12, 2021
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7D84
| 34-fold symmetry Salmonella S ring formed by full-length FliF | Descriptor: | Flagellar M-ring protein | Authors: | Kawamoto, A, Miyata, T, Makino, F, Kinoshita, M, Minamino, T, Imada, K, Kato, T, Namba, K. | Deposit date: | 2020-10-07 | Release date: | 2021-05-19 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Native flagellar MS ring is formed by 34 subunits with 23-fold and 11-fold subsymmetries. Nat Commun, 12, 2021
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7DDA
| Envelope protein VP37 a crystal structure from White Spot Syndrome Virus | Descriptor: | Envelope protein, SULFATE ION | Authors: | Somsoros, W, Sangawa, T, Takebe, K, Attarataya, J, Suzuki, M, Khunrae, P. | Deposit date: | 2020-10-28 | Release date: | 2021-06-23 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Crystal structure of the C-terminal domain of envelope protein VP37 from white spot syndrome virus reveals sulphate binding sites responsible for heparin binding. J.Gen.Virol., 102, 2021
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