4GQ4

Human menin with bound inhibitor MI-2-2

Summary for 4GQ4

Entry DOI	10.2210/pdb4gq4/pdb
Related	4GPQ 4GQ3 4GQ6
Descriptor	Menin, 4-[4-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)piperazin-1-yl]-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidine, UNKNOWN ATOM OR ION, ... (8 entities in total)
Functional Keywords	tumor suppressor, nucleus, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O00255
Total number of polymer chains	1
Total formula weight	56395.28
Authors	Shi, A.,Murai, M.J.,He, S.,Lund, G.L.,Hartley, T.,Purohit, T.,Reddy, G.,Chruszcz, M.,Grembecka, J.,Cierpicki, T. (deposition date: 2012-08-22, release date: 2012-09-19, Last modification date: 2024-02-28)
Primary citation	Shi, A.,Murai, M.J.,He, S.,Lund, G.,Hartley, T.,Purohit, T.,Reddy, G.,Chruszcz, M.,Grembecka, J.,Cierpicki, T. Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia. Blood, 120:4461-4469, 2012 Cited by PubMed: 22936661 DOI: 10.1182/blood-2012-05-429274 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.27 Å)

Structure validation