7DCZ
 
 | | Crystal Structure of BACE1 in complex with N-{3-[(4S)-2-amino-4-methyl-4H-1,3-thiazin-4-yl]-4- fluorophenyl}-5-cyanopyridine-2-carboxamide | | Descriptor: | Beta-secretase 1, GLYCEROL, IODIDE ION, ... | | Authors: | Koriyama, Y, Hori, A, Ito, H, Yonezawa, S, Baba, Y, Tanimoto, N, Ueno, T, Yamamoto, S, Yamamoto, T, Asada, N, Morimoto, K, Einaru, S, Sakai, K, Kanazu, T, Matsuda, A, Yamaguchi, Y, Oguma, T, Timmers, M, Tritsmans, L, Kusakabe, K.I, Kato, A, Sakaguchi, G. | | Deposit date: | 2020-10-27 | | Release date: | 2021-03-10 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based beta-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial.
J.Med.Chem., 64, 2021
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2K16
 | | Solution structure of the free TAF3 PHD domain | | Descriptor: | Transcription initiation factor TFIID subunit 3, ZINC ION | | Authors: | van Ingen, H, van Schaik, F.M.A, Wienk, H, Timmers, M, Boelens, R. | | Deposit date: | 2008-02-22 | | Release date: | 2008-07-15 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Recognition of the H3K4me3 mark by the TAF3-PHD finger
To be Published
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2K17
 | | Solution structure of the TAF3 PHD domain in complex with a H3K4me3 peptide | | Descriptor: | H3K4me3 peptide, Transcription initiation factor TFIID subunit 3, ZINC ION | | Authors: | van Ingen, H, van Schaik, F.M.A, Wienk, H, Timmers, M, Boelens, R. | | Deposit date: | 2008-02-22 | | Release date: | 2008-07-15 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Recognition of the H3K4me3 mark by the TAF3-PHD finger
To be Published
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