7CY8

Crystal Structure of CMD1 in complex with 5mC-DNA and vitamin C

Summary for 7CY8

• Entry DOI: 10.2210/pdb7cy8/pdb
• Descriptor: Maltodextrin-binding protein,5-methylcytosine-modifying enzyme 1, DNA (5'-D(P*(5CM)P*GP*CP*GP*CP*GP*GP*GP*A)-3'), ASCORBIC ACID, ... (7 entities in total)
• Functional Keywords: tet, vitamin c, dioxygenase, 5gmc, dna modification, 2-oxoglutarate, transferase
• Biological source: Escherichia coli; More
• Total number of polymer chains: 3
• Total formula weight: 107953.26

Authors

Li, W.,Zhang, T.,Sun, M.,Ding, J. (deposition date: 2020-09-03, release date: 2020-12-30, Last modification date: 2023-11-29)

• Primary citation: Li, W.,Zhang, T.,Sun, M.,Shi, Y.,Zhang, X.J.,Xu, G.L.,Ding, J.; Molecular mechanism for vitamin C-derived C 5 -glyceryl-methylcytosine DNA modification catalyzed by algal TET homologue CMD1.; Nat Commun, 12:744-744, 2021; PubMed: 33531488; DOI: 10.1038/s41467-021-21061-2

Experimental method

X-RAY DIFFRACTION (2.4 Å)