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8JRU
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BU of 8jru by Molmil
Cryo-EM structure of the glucagon receptor bound to beta-arrestin 1 in ligand-free state
Descriptor: Beta-arrestin 1 and single-chain fragment variable 30 (scFv30), HA signal peptide,HPC4 purification tag,Glucagon receptor,C-terminal tail of Vasopressin V2 receptor, Nanobody 32, ...
Authors:Chen, K, Zhang, C, Lin, S, Zhao, Q, Wu, B.
Deposit date:2023-06-17
Release date:2023-08-16
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Tail engagement of arrestin at the glucagon receptor.
Nature, 620, 2023
8JRV
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BU of 8jrv by Molmil
Cryo-EM structure of the glucagon receptor bound to glucagon and beta-arrestin 1
Descriptor: Beta-arrestin 1 and single-chain fragment variable 30 (scFv30), Glucagon, HA signal peptide,HPC4 purification tag,Glucagon receptor,C-terminal tail of Vasopressin V2 receptor, ...
Authors:Chen, K, Zhang, C, Lin, S, Zhao, Q, Wu, B.
Deposit date:2023-06-17
Release date:2023-08-16
Last modified:2023-09-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Tail engagement of arrestin at the glucagon receptor.
Nature, 620, 2023
5ZKQ
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BU of 5zkq by Molmil
Crystal structure of the human platelet-activating factor receptor in complex with ABT-491
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide, Platelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor, ...
Authors:Cao, C, Zhao, Q, Zhang, X.C, Wu, B.
Deposit date:2018-03-25
Release date:2018-06-20
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
Nat. Struct. Mol. Biol., 25, 2018
5ZKP
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BU of 5zkp by Molmil
Crystal structure of the human platelet-activating factor receptor in complex with SR 27417
Descriptor: FLAVIN MONONUCLEOTIDE, N1,N1-dimethyl-N2-[(pyridin-3-yl)methyl]-N2-{4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl}ethane-1,2-diamine, Platelet-activating factor receptor,Flavodoxin,Platelet-activating factor receptor
Authors:Cao, C, Zhao, Q, Zhang, X.C, Wu, B.
Deposit date:2018-03-25
Release date:2018-06-20
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
Nat. Struct. Mol. Biol., 25, 2018
7XXI
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BU of 7xxi by Molmil
Cryo-EM structure of the purinergic receptor P2Y12R in complex with 2MeSADP and Gi
Descriptor: 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Tan, Q, Li, B, Han, S, Zhao, Q, Wu, B.
Deposit date:2022-05-30
Release date:2023-06-07
Last modified:2023-09-20
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R.
Protein Cell, 14, 2023
7XXH
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BU of 7xxh by Molmil
Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11
Descriptor: 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), Guanine nucleotide-binding protein G(11) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Tan, Q, Li, B, Han, S, Zhao, Q, Wu, B.
Deposit date:2022-05-30
Release date:2023-06-07
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R.
Protein Cell, 14, 2023
6BNS
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BU of 6bns by Molmil
STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND TETHERED WITH SRC co-activator peptide and Compound 25a AKA BICYCLIC HEXAFLUOROISOPROPYL 2 ALCOHOL SULFONAMIDES
Descriptor: 2-[(2S)-4-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]-N-(2-hydroxy-2-methylpropyl)acetamide, Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 Chimera
Authors:DHAR, T.G, GONG, H, WEINSTEIN, D.S, LU, Z, DUAN, J.J.W, STACHURA, S, HAQUE, L, KARMAKAR, A, HEMAGIRI, H, RAUT, D.K, GUPTA, A.K, KHAN, J.A, SACK, J.S, CAMAC, D.M, PUDZIANOWSKI, A.A, WU, D.R, YARDE, M, SHEN, D.R, BOROWSKI, V, XIE, J.H, SUN, H, ARIENZO, C.D, DABROS, M, GALELLA, M.A, WANG, F, WEIGELT, C.A, ZHAO, Q, FOSTER, W, SOMERVILLE, J.E, SALTER-CID, L.M, BARRISH, J.C, CARTER, P.H.
Deposit date:2017-11-17
Release date:2017-12-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (ROR gamma /RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity.
Bioorg. Med. Chem. Lett., 28, 2018
7XBW
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BU of 7xbw by Molmil
Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with Gi1
Descriptor: CHOLESTEROL, CX3C chemokine receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2022-03-22
Release date:2022-07-13
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Activation of the human chemokine receptor CX3CR1 regulated by cholesterol.
Sci Adv, 8, 2022
7XBX
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BU of 7xbx by Molmil
Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2022-03-22
Release date:2022-07-13
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Activation of the human chemokine receptor CX3CR1 regulated by cholesterol.
Sci Adv, 8, 2022
5GJB
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BU of 5gjb by Molmil
Zika virus NS3 helicase in complex with ssRNA
Descriptor: NS3 helicase, RNA (5'-R(*AP*GP*AP*UP*CP*AP*A)-3')
Authors:Tian, H.L, Ji, X.Y, Yang, X.Y, Zhang, Z.X, Lu, Z.K, Yang, K.L, Chen, C, Zhao, Q, Chi, H, Mu, Z.Y, Xie, W, Wang, Z.F, Lou, H.Q, Yang, H.T, Rao, Z.H.
Deposit date:2016-06-28
Release date:2016-07-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Structural basis of Zika virus helicase in recognizing its substrates
Protein Cell, 7, 2016
5GJC
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BU of 5gjc by Molmil
Zika virus NS3 helicase in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, NS3 helicase
Authors:Tian, H.L, Ji, X.Y, Yang, X.Y, Zhang, Z.X, Lu, Z.K, Yang, K.L, Chen, C, Zhao, Q, Chi, H, Mu, Z.Y, Xie, W, Wang, Z.F, Lou, H.Q, Yang, H.T, Rao, Z.H.
Deposit date:2016-06-28
Release date:2016-07-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Structural basis of Zika virus helicase in recognizing its substrates
Protein Cell, 7, 2016
2OIE
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BU of 2oie by Molmil
Crystal structure of RS21-C6 core segment RSCUT
Descriptor: RS21-C6, SULFATE ION
Authors:Wu, B, Liu, Y, Zhao, Q, Liao, S, Zhang, J, Bartlam, M, Chen, W, Rao, Z.
Deposit date:2007-01-10
Release date:2007-03-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of RS21-C6, Involved in Nucleoside Triphosphate Pyrophosphohydrolysis
J.Mol.Biol., 367, 2007
2OIG
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BU of 2oig by Molmil
Crystal structure of RS21-C6 core segment and dm5CTP complex
Descriptor: 2'-DEOXY-5-METHYLCYTIDINE 5'-(TETRAHYDROGEN TRIPHOSPHATE), RS21-C6
Authors:Wu, B, Liu, Y, Zhao, Q, Liao, S, Zhang, J, Bartlam, M, Chen, W, Rao, Z.
Deposit date:2007-01-11
Release date:2007-03-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal Structure of RS21-C6, Involved in Nucleoside Triphosphate Pyrophosphohydrolysis
J.Mol.Biol., 367, 2007
7F8X
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BU of 7f8x by Molmil
Crystal structure of the cholecystokinin receptor CCKAR in complex with NN9056
Descriptor: ASP-SMF-NLE-GLY-TRP-NLE-OEM-MEA-NH2 (NN9056), Cholecystokinin receptor type A,Endolysin
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-12-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021
5Y6M
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BU of 5y6m by Molmil
Zika virus helicase in complex with ADP-AlF3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Helicase domain from Genome polyprotein, ...
Authors:Yang, X.Y, Chen, C, Tian, H.L, Chi, H, Mu, Z.Y, Zhang, T.Q, Yang, K.L, Zhao, Q, Liu, X.H, Wang, Z.F, Ji, X.Y, Yang, H.T.
Deposit date:2017-08-12
Release date:2018-07-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Mechanism of ATP hydrolysis by the Zika virus helicase.
FASEB J., 32, 2018
7F8Y
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BU of 7f8y by Molmil
Crystal structure of the cholecystokinin receptor CCKAR in complex with devazepide
Descriptor: N-[(3S)-1-methyl-2-oxidanylidene-5-phenyl-3H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide, fusion protein of Cholecystokinin receptor type A and Endolysin
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-10-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021
7F8U
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BU of 7f8u by Molmil
Crystal structure of the cholecystokinin receptor CCKAR in complex with lintitript
Descriptor: 2-[2-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]indol-1-yl]ethanoic acid, Fusion protein of Cholecystokinin receptor type A and Endolysin
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-10-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021
7F8W
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BU of 7f8w by Molmil
Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gq
Descriptor: Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-10-13
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021
7F8V
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BU of 7f8v by Molmil
Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gi
Descriptor: Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2021-07-02
Release date:2021-10-13
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of the human cholecystokinin receptors bound to agonists and antagonists.
Nat.Chem.Biol., 17, 2021
5Y6N
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BU of 5y6n by Molmil
Zika virus helicase in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Helicase domain from Genome polyprotein, MANGANESE (II) ION
Authors:Yang, X.Y, Chen, C, Tian, H.L, Chi, H, Mu, Z.Y, Zhang, T.Q, Yang, K.L, Zhao, Q, Liu, X.H, Wang, Z.F, Ji, X.Y, Yang, H.T.
Deposit date:2017-08-12
Release date:2018-07-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.571 Å)
Cite:Mechanism of ATP hydrolysis by the Zika virus helicase.
FASEB J., 32, 2018
7DDZ
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BU of 7ddz by Molmil
The Crystal Structure of Human Neuropeptide Y Y2 Receptor with JNJ-31020028
Descriptor: FLAVIN MONONUCLEOTIDE, Human Neuropeptide Y Y2 Receptor fusion protein, ~{N}-[4-[4-[(1~{S})-2-(diethylamino)-2-oxidanylidene-1-phenyl-ethyl]piperazin-1-yl]-3-fluoranyl-phenyl]-2-pyridin-3-yl-benzamide
Authors:Tang, T, Han, S, Zhao, Q, Wu, B.
Deposit date:2020-10-30
Release date:2021-01-27
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for ligand recognition of the neuropeptide Y Y 2 receptor.
Nat Commun, 12, 2021
8JD2
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BU of 8jd2 by Molmil
Cryo-EM structure of G protein-free mGlu2-mGlu3 heterodimer in Acc state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
Authors:Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
Deposit date:2023-05-12
Release date:2023-06-21
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JD1
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BU of 8jd1 by Molmil
Cryo-EM structure of mGlu2-mGlu3 heterodimer in Rco state
Descriptor: CHOLESTEROL, GLUTAMIC ACID, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ...
Authors:Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
Deposit date:2023-05-12
Release date:2023-06-21
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JCW
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BU of 8jcw by Molmil
Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 and NAM563 (dimerization mode I)
Descriptor: 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
Authors:Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
Deposit date:2023-05-12
Release date:2023-06-21
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023
8JD6
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BU of 8jd6 by Molmil
Cryo-EM structure of Gi1-bound metabotropic glutamate receptor mGlu4
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-3, ...
Authors:Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B.
Deposit date:2023-05-12
Release date:2023-06-21
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers.
Cell Res., 33, 2023

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