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Pig R615C RyR1 in complex with CaM, EGTA (class 1, open)
Descriptor:	Calmodulin-1, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine Receptor, ...
Authors:	Woll, K.W, Haji-Ghassemi, O, Van Petegem, F.
Deposit date:	2020-05-21
Release date:	2021-01-13
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM. Nat Commun, 12, 2021

6X33

Wt pig RyR1 in complex with apoCaM, EGTA condition (class 3, open)
Descriptor:	Calmodulin-1, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine Receptor, ...
Authors:	Woll, K.W, Haji-Ghassemi, O, Van Petegem, F.
Deposit date:	2020-05-21
Release date:	2021-01-13
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM. Nat Commun, 12, 2021

6X32

Wt pig RyR1 in complex with apoCaM, EGTA condition (class 1 and 2, closed)
Descriptor:	Calmodulin-1, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine Receptor, ...
Authors:	Woll, K.W, Haji-Ghassemi, O, Van Petegem, F.
Deposit date:	2020-05-21
Release date:	2021-01-13
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (3.8 Å)
Cite:	Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM. Nat Commun, 12, 2021

6Y4P

Calmodulin N53I variant bound to cardiac ryanodine receptor (RyR2) calmodulin binding domain
Descriptor:	CALCIUM ION, Calmodulin-1, Ryanodine receptor 2
Authors:	Lau, K, Nielsen, L.H, Holt, C, Brohus, M, Sorensen, A.B, Larsen, K.T, Sommer, C, Van Petegem, F, Overgaard, M.T, Wimmer, R.
Deposit date:	2020-02-21
Release date:	2020-04-29
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.13325572 Å)
Cite:	The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor. J.Biol.Chem., 295, 2020

6Y4O

Calmodulin bound to cardiac ryanodine receptor (RyR2) calmodulin binding domain
Descriptor:	CALCIUM ION, Calmodulin-2, Ryanodine receptor 2
Authors:	Lau, K, Nielsen, L.H, Holt, C, Brohus, M, Sorensen, A.B, Larsen, K.T, Sommer, C, Van Petegem, F, Overgaard, M.T, Wimmer, R.
Deposit date:	2020-02-21
Release date:	2020-04-29
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.83549082 Å)
Cite:	The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor. J.Biol.Chem., 295, 2020

1H71

Psychrophilic Protease from Pseudoalteromonas 'TAC II 18'
Descriptor:	CALCIUM ION, SERRALYSIN, ZINC ION
Authors:	Villeret, V, Van Petegem, F, Aghajari, N, Chessa, J.-P, Gerday, C, Haser, R, Van Beeumen, J.
Deposit date:	2001-07-02
Release date:	2003-02-13
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Crystal Structures of a Psychrophilic Metalloprotease Reveal New Insights Into Catalysis by Cold-Adapted Proteases Proteins: Struct.,Funct., Genet., 50, 2003

6VSV

Crystal structure of a disease mutant of the Voltage-gated Sodium Channel Beta 4 subunit extracellular domain
Descriptor:	Sodium channel subunit beta-4
Authors:	Das, S, Van Petegem, F.
Deposit date:	2020-02-12
Release date:	2020-08-26
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.62 Å)
Cite:	Biophysical Investigation of Sodium Channel Interaction with beta-Subunit Variants Associated with Arrhythmias. Bioelectricity, 2, 2020

6VRR

Crystal structure of a disease mutant of the Voltage-gated Sodium Channel Beta 2 subunit extracellular domain
Descriptor:	GLYCEROL, Sodium channel subunit beta-2
Authors:	Das, S, Van Petegem, F.
Deposit date:	2020-02-09
Release date:	2020-08-26
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.45 Å)
Cite:	Biophysical Investigation of Sodium Channel Interaction with beta-Subunit Variants Associated with Arrhythmias. Bioelectricity, 2, 2020

6B27

Crystal structure of human STAC2 Tandem SH3 Domains (296-411) in complex with a CaV1.1 II-III loop peptide
Descriptor:	CHLORIDE ION, SH3 and cysteine-rich domain-containing protein 2, SULFATE ION, ...
Authors:	Wong King Yuen, S.M, Van Petegem, F.
Deposit date:	2017-09-19
Release date:	2017-10-25
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.73 Å)
Cite:	Structural insights into binding of STAC proteins to voltage-gated calcium channels. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

6B28

Crystal structure of human STAC2 Tandem SH3 Domains Q347I (296-411)
Descriptor:	SH3 and cysteine-rich domain-containing protein 2
Authors:	Wong King Yuen, S.M, Tung, C.C, Van Petegem, F.
Deposit date:	2017-09-19
Release date:	2017-10-25
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.55 Å)
Cite:	Structural insights into binding of STAC proteins to voltage-gated calcium channels. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

6B26

Crystal structure of human STAC2 Tandem SH3 Domains (296-411)
Descriptor:	SH3 and cysteine-rich domain-containing protein 2
Authors:	Wong King Yuen, S.M, Van Petegem, F.
Deposit date:	2017-09-19
Release date:	2017-10-25
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.2 Å)
Cite:	Structural insights into binding of STAC proteins to voltage-gated calcium channels. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

6B25

Crystal structure of human STAC1 Tandem SH3 Domains (288-402)
Descriptor:	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SH3 and cysteine-rich domain-containing protein
Authors:	Wong King Yuen, S.M, Van Petegem, F.
Deposit date:	2017-09-19
Release date:	2017-10-25
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.39 Å)
Cite:	Structural insights into binding of STAC proteins to voltage-gated calcium channels. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

6B29

Crystal structure of the second SH3 domain of STAC3 (309-364)
Descriptor:	SH3 and cysteine-rich domain-containing protein 3
Authors:	Wong King Yuen, S.M, Van Petegem, F.
Deposit date:	2017-09-19
Release date:	2017-10-25
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.3 Å)
Cite:	Structural insights into binding of STAC proteins to voltage-gated calcium channels. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

6U3D

1.75 Angstrom crystal structure of the N53I Ca-CaM:CaV1.2 IQ domain complex
Descriptor:	CALCIUM ION, Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C
Authors:	Wang, K, Van Petegem, F.
Deposit date:	2019-08-21
Release date:	2020-02-19
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca2+binding and cause misfolding. J. Physiol. (Lond.), 598, 2020

6ULB

Sex Hormone-binding globulin mutant E176K in complex with Danazol
Descriptor:	CALCIUM ION, Danazol, Sex hormone-binding globulin
Authors:	Round, P.W, Das, S, Van Petegem, F.
Deposit date:	2019-10-07
Release date:	2020-10-21
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Structural and biochemical analyses of danazol interactions with sex hormone-binding globulin and effects on androgen action To Be Published

6U3A

1.65 Angstrom crystal structure of the N97S Ca-CaM:CaV1.2 IQ domain complex
Descriptor:	CALCIUM ION, Calmodulin-1, SODIUM ION, ...
Authors:	Wang, K, Van Petegem, F.
Deposit date:	2019-08-21
Release date:	2020-02-19
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca2+binding and cause misfolding. J. Physiol. (Lond.), 598, 2020

6U39

2.4 Angstrom crystal structure of the D129G Ca-CaM:CaV1.2 IQ domain complex
Descriptor:	CALCIUM ION, Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C
Authors:	Wang, K, Van Petegem, F.
Deposit date:	2019-08-21
Release date:	2020-02-19
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca2+binding and cause misfolding. J. Physiol. (Lond.), 598, 2020

6U3B

1.7 Angstrom crystal structure of the Q135P Ca-CaM:CaV1.2 IQ domain complex
Descriptor:	CALCIUM ION, Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C
Authors:	Wang, K, Van Petegem, F.
Deposit date:	2019-08-21
Release date:	2020-02-19
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca2+binding and cause misfolding. J. Physiol. (Lond.), 598, 2020

6VHO

Glycoside hydrolase family 16 endo-glucanase from Bacteroides ovatus in complex with G4G4G3G-NHCOCH2Br
Descriptor:	Glycosyl hydrolase family 16, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-3)-N-acetyl-beta-D-glucopyranosylamine
Authors:	Tamura, K, Brumer, H, van Petegem, F.
Deposit date:	2020-01-10
Release date:	2021-01-13
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.148 Å)
Cite:	Orthogonal Active-Site Labels for Mixed-Linkage endo-beta-Glucanases. Acs Chem.Biol., 16, 2021

6UY7

Crystal structure of the STAC3 tandem SH3 domains - P269R
Descriptor:	1,2-ETHANEDIOL, SH3 and cysteine-rich domain-containing protein 3
Authors:	Rufenach, B, Van Petegem, F.
Deposit date:	2019-11-12
Release date:	2020-06-17
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.105 Å)
Cite:	Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling. Structure, 28, 2020

6UY8

Crystal structure of the STAC3 tandem SH3 domains - P269R, K329N
Descriptor:	1,2-ETHANEDIOL, CHLORIDE ION, SH3 and cysteine-rich domain-containing protein 3
Authors:	Rufenach, B, Van Petegem, F.
Deposit date:	2019-11-12
Release date:	2020-06-17
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.649 Å)
Cite:	Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling. Structure, 28, 2020

6UY9

Crystal structure of the STAC3 tandem SH3 domains - P269R, W284S
Descriptor:	1,2-ETHANEDIOL, SH3 and cysteine-rich domain-containing protein 3, SODIUM ION
Authors:	Rufenach, B, Van Petegem, F.
Deposit date:	2019-11-12
Release date:	2020-06-17
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling. Structure, 28, 2020

6W1N

Pig Ryanodine Receptor (WT) in 5mM EGTA condition
Descriptor:	Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine Receptor, ZINC ION
Authors:	Woll, K.W, Haji-Ghassemi, O, Van Petegem, F.
Deposit date:	2020-03-04
Release date:	2021-01-06
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (4 Å)
Cite:	Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM. Nat Commun, 12, 2021

6DLG

Crystal structure of a SHIP1 surface entropy reduction mutant
Descriptor:	ISOPROPYL ALCOHOL, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Authors:	Gardill, B.R, Cheung, S.T, Mui, A.L, Van Petegem, F.
Deposit date:	2018-06-01
Release date:	2019-06-05
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.499 Å)
Cite:	Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes Biorxiv, 2020

7KV6

Surface glycan-binding protein B from Bacteroides fluxus in complex with mixed-linkage glucotriose
Descriptor:	GUANIDINE, PKD domain protein, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose
Authors:	Tamura, K, Brumer, H, Van Petegem, F.
Deposit date:	2020-11-26
Release date:	2021-02-17
Last modified:	2024-03-06
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Distinct protein architectures mediate species-specific beta-glucan binding and metabolism in the human gut microbiota. J.Biol.Chem., 296, 2021

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