6B27

Crystal structure of human STAC2 Tandem SH3 Domains (296-411) in complex with a CaV1.1 II-III loop peptide

Summary for 6B27

Entry DOI	10.2210/pdb6b27/pdb
Descriptor	SH3 and cysteine-rich domain-containing protein 2, Voltage-dependent L-type calcium channel subunit alpha-1S, SULFATE ION, ... (5 entities in total)
Functional Keywords	excitation-contraction coupling, ion channel adaptor protein, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	91469.31
Authors	Wong King Yuen, S.M.,Van Petegem, F. (deposition date: 2017-09-19, release date: 2017-10-25, Last modification date: 2024-03-13)
Primary citation	Wong King Yuen, S.M.,Campiglio, M.,Tung, C.C.,Flucher, B.E.,Van Petegem, F. Structural insights into binding of STAC proteins to voltage-gated calcium channels. Proc. Natl. Acad. Sci. U.S.A., 114:E9520-E9528, 2017 Cited by PubMed: 29078335 DOI: 10.1073/pnas.1708852114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation