6Y4O

Calmodulin bound to cardiac ryanodine receptor (RyR2) calmodulin binding domain

Summary for 6Y4O

• Entry DOI: 10.2210/pdb6y4o/pdb
• Descriptor: Calmodulin-2, Ryanodine receptor 2, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: ion channel, calcium, calmodulin, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 20491.09

Authors

Lau, K.,Nielsen, L.H.,Holt, C.,Brohus, M.,Sorensen, A.B.,Larsen, K.T.,Sommer, C.,Van Petegem, F.,Overgaard, M.T.,Wimmer, R. (deposition date: 2020-02-21, release date: 2020-04-29, Last modification date: 2024-01-24)

• Primary citation: Holt, C.,Hamborg, L.,Lau, K.,Brohus, M.,Sorensen, A.B.,Larsen, K.T.,Sommer, C.,Van Petegem, F.,Overgaard, M.T.,Wimmer, R.; The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor.; J.Biol.Chem., 295:7620-7634, 2020; PubMed: 32317284; DOI: 10.1074/jbc.RA120.013430

Experimental method

X-RAY DIFFRACTION (1.83549081766 Å)