6Y4P
Calmodulin N53I variant bound to cardiac ryanodine receptor (RyR2) calmodulin binding domain
Summary for 6Y4P
Entry DOI | 10.2210/pdb6y4p/pdb |
Descriptor | Calmodulin-1, Ryanodine receptor 2, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | ion channel, calcium, calmodulin, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 20490.15 |
Authors | Lau, K.,Nielsen, L.H.,Holt, C.,Brohus, M.,Sorensen, A.B.,Larsen, K.T.,Sommer, C.,Van Petegem, F.,Overgaard, M.T.,Wimmer, R. (deposition date: 2020-02-21, release date: 2020-04-29, Last modification date: 2024-01-24) |
Primary citation | Holt, C.,Hamborg, L.,Lau, K.,Brohus, M.,Sorensen, A.B.,Larsen, K.T.,Sommer, C.,Van Petegem, F.,Overgaard, M.T.,Wimmer, R. The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor. J.Biol.Chem., 295:7620-7634, 2020 Cited by PubMed: 32317284DOI: 10.1074/jbc.RA120.013430 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.13325578805 Å) |
Structure validation
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