8Q5P
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![BU of 8q5p by Molmil](/molmil-images/mine/8q5p) | Structure of the lysine methyltransferase SETD2 in complex with a peptide derived from human tyrosine kinase ACK1 | Descriptor: | Activated CDC42 kinase 1, Histone-lysine N-methyltransferase SETD2, S-ADENOSYLMETHIONINE, ... | Authors: | Mechaly, A, Le Coadou, L, Dupret, J.M, Haouz, A, Rodrigues Lima, F. | Deposit date: | 2023-08-09 | Release date: | 2024-04-24 | Method: | X-RAY DIFFRACTION (1.814 Å) | Cite: | Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2. Biochem.Biophys.Res.Commun., 695, 2024
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2ISO
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![BU of 2iso by Molmil](/molmil-images/mine/2iso) | Ternary complex of DNA Polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-difluoromethylene triphosphate | Descriptor: | 2'-DEOXY-5'-O-[({[DIFLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL}OXY)(HYDROXY)PHOSPHORYL]GUANOSINE, 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ... | Authors: | Sucato, C.A, Upton, T.G, Kashemirov, B.A, Martinek, V, Xiang, Y, Beard, W.A. | Deposit date: | 2006-10-18 | Release date: | 2007-01-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Modifying the beta,gamma Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase beta. Biochemistry, 46, 2007
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2ISP
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![BU of 2isp by Molmil](/molmil-images/mine/2isp) | Ternary complex of DNA Polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-methylene triphosphate | Descriptor: | 2'-DEOXY-5'-O-(HYDROXY{[HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]OXY}PHOSPHORYL)GUANOSINE, 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ... | Authors: | Sucato, C.A, Upton, T.G, Kashemirov, B.A, Martinek, V, Xiang, Y, Beard, W.A. | Deposit date: | 2006-10-18 | Release date: | 2007-01-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Modifying the beta,gamma Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase beta. Biochemistry, 46, 2007
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2IEE
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![BU of 2iee by Molmil](/molmil-images/mine/2iee) | Crystal Structure of YCKB_BACSU from Bacillus subtilis. Northeast Structural Genomics Consortium target SR574. | Descriptor: | Probable ABC transporter extracellular-binding protein yckB | Authors: | Kuzin, A.P, Su, M, Jayaraman, S, Chen, X.C, Jang, M, Cunningham, K, Ma, C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2006-09-18 | Release date: | 2006-10-03 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of probable ABC transporter extracellular-binding protein yckB from Bacillus subtilis. To be Published
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7JQ8
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![BU of 7jq8 by Molmil](/molmil-images/mine/7jq8) | Solution NMR structure of human Brd3 ET domain | Descriptor: | Bromodomain-containing protein 3, Integrase peptide | Authors: | Aiyer, S, Swapna, G.V.T, Roth, J.M, Montelione, G.T. | Deposit date: | 2020-08-10 | Release date: | 2021-06-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins. Structure, 29, 2021
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7JMY
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7JYN
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![BU of 7jyn by Molmil](/molmil-images/mine/7jyn) | Solution NMR structure of human Brd3 ET complexed with NSD3(148-184) peptide | Descriptor: | Bromodomain-containing protein 3, Histone-lysine N-methyltransferase NSD3 | Authors: | Aiyer, S, Swapna, G.V.T, Roth, M.J, Montelione, G.T. | Deposit date: | 2020-08-31 | Release date: | 2021-06-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins. Structure, 29, 2021
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7KJP
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![BU of 7kjp by Molmil](/molmil-images/mine/7kjp) | Disulfide Stabilized Norovirus GI.1 VLP Shell Region | Descriptor: | Capsid protein VP1 | Authors: | Gorman, J, Kwong, P.D. | Deposit date: | 2020-10-26 | Release date: | 2020-12-02 | Last modified: | 2020-12-30 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes. NPJ Vaccines, 5, 2020
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6PA1
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![BU of 6pa1 by Molmil](/molmil-images/mine/6pa1) | Killer cell immunoglobulin-like receptor 2DL2 in complex with HLA-C*07:02 | Descriptor: | ARG-TYR-ARG-PRO-GLY-THR-VAL-ALA-LEU, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | Authors: | Moradi, S, Rossjohn, J, Vivian, J.P. | Deposit date: | 2019-06-11 | Release date: | 2020-12-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C. Nat Commun, 12, 2021
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6PLF
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![BU of 6plf by Molmil](/molmil-images/mine/6plf) | Crystal structure of human PHGDH complexed with Compound 1 | Descriptor: | 1,2-ETHANEDIOL, 4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic acid, D-3-phosphoglycerate dehydrogenase | Authors: | Olland, A, Lakshminarasimhan, D, White, A, Suto, R.K. | Deposit date: | 2019-06-30 | Release date: | 2019-07-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorg.Med.Chem.Lett., 29, 2019
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6QV9
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![BU of 6qv9 by Molmil](/molmil-images/mine/6qv9) | |
6QV8
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![BU of 6qv8 by Molmil](/molmil-images/mine/6qv8) | |
6RGS
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![BU of 6rgs by Molmil](/molmil-images/mine/6rgs) | |
8RXN
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![BU of 8rxn by Molmil](/molmil-images/mine/8rxn) | REFINEMENT OF RUBREDOXIN FROM DESULFOVIBRIO VULGARIS AT 1.0 ANGSTROMS WITH AND WITHOUT RESTRAINTS | Descriptor: | FE (III) ION, RUBREDOXIN, SULFATE ION | Authors: | Dauter, Z, Sieker, L, Wilson, K. | Deposit date: | 1991-08-26 | Release date: | 1993-10-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Refinement of rubredoxin from Desulfovibrio vulgaris at 1.0 A with and without restraints. Acta Crystallogr.,Sect.B, 48, 1992
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8U5G
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![BU of 8u5g by Molmil](/molmil-images/mine/8u5g) | Crystal structure of the co-expressed SDS22:PP1:I3 complex | Descriptor: | E3 ubiquitin-protein ligase PPP1R11, FE (III) ION, PHOSPHATE ION, ... | Authors: | Choy, M.S, Peti, W, Page, R. | Deposit date: | 2023-09-12 | Release date: | 2023-12-06 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The SDS22:PP1:I3 complex: SDS22 binding to PP1 loosens the active site metal to prime metal exchange. J.Biol.Chem., 300, 2023
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7DRZ
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![BU of 7drz by Molmil](/molmil-images/mine/7drz) | |
7DS0
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7DS1
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![BU of 7ds1 by Molmil](/molmil-images/mine/7ds1) | Crystal structure of Aspergillus oryzae Rib2 deaminase in complex with DARIPP (C-terminal deletion mutant at pH 6.5) | Descriptor: | CMP/dCMP-type deaminase domain-containing protein, ZINC ION, [(2~{R},3~{S},4~{S})-5-[[2,5-bis(azanyl)-6-oxidanylidene-1~{H}-pyrimidin-4-yl]amino]-2,3,4-tris(oxidanyl)pentyl] dihydrogen phosphate | Authors: | Chen, S.C, Liaw, S.H, Hsu, C.H. | Deposit date: | 2020-12-30 | Release date: | 2021-07-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Crystal structures of Aspergillus oryzae Rib2 deaminase: the functional mechanism involved in riboflavin biosynthesis. Iucrj, 8, 2021
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7DRY
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![BU of 7dry by Molmil](/molmil-images/mine/7dry) | Crystal structure of Aspergillus oryzae Rib2 deaminase | Descriptor: | CMP/dCMP-type deaminase domain-containing protein, SULFATE ION, ZINC ION | Authors: | Chen, S.C, Liaw, S.H, Hsu, C.H. | Deposit date: | 2020-12-30 | Release date: | 2021-07-14 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Crystal structures of Aspergillus oryzae Rib2 deaminase: the functional mechanism involved in riboflavin biosynthesis. Iucrj, 8, 2021
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8TUB
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![BU of 8tub by Molmil](/molmil-images/mine/8tub) | HLA B7:02 with HPNGYKSLSTL | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | Authors: | Littler, D.R, Rossjohn, J, Chaurasia, P, Petersen, J. | Deposit date: | 2023-08-16 | Release date: | 2024-03-13 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | CD8 + T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age. Nat Commun, 15, 2024
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8TUH
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![BU of 8tuh by Molmil](/molmil-images/mine/8tuh) | HLA B7:02 with RPIIRPATL | Descriptor: | 1,2-ETHANEDIOL, ARG-PRO-ILE-ILE-ARG-PRO-ALA-THR-LEU, Beta-2-microglobulin, ... | Authors: | Littler, D.R, Rossjohn, J, Chaurasia, P, Petersen, J. | Deposit date: | 2023-08-16 | Release date: | 2024-03-13 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.200106 Å) | Cite: | CD8 + T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age. Nat Commun, 15, 2024
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8TWQ
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![BU of 8twq by Molmil](/molmil-images/mine/8twq) | Structure of bacteriophage lambda RexA protein | Descriptor: | CADMIUM ION, Protein rexA, SULFATE ION | Authors: | Adams, M.C, Chappie, J.S, Schiltz, C.J. | Deposit date: | 2023-08-21 | Release date: | 2024-04-17 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | The crystal structure of bacteriophage lambda RexA provides novel insights into the DNA binding properties of Rex-like phage exclusion proteins. Nucleic Acids Res., 52, 2024
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8UMO
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![BU of 8umo by Molmil](/molmil-images/mine/8umo) | Murine CD94-NKG2A receptor in complex with Qa-1b presenting AMAPRTLLL | Descriptor: | BROMIDE ION, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ... | Authors: | MacLachlan, B.J, Rossjohn, J, Vivian, J.P. | Deposit date: | 2023-10-18 | Release date: | 2024-01-17 | Last modified: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the murine CD94-NKG2A receptor in complex with Qa-1 b presenting an MHC-I leader peptide. Febs J., 291, 2024
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8TC9
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![BU of 8tc9 by Molmil](/molmil-images/mine/8tc9) | Human asparaginyl-tRNA synthetase bound to OSM-S-106 | Descriptor: | Asparagine--tRNA ligase, cytoplasmic, GLYCEROL, ... | Authors: | Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | Deposit date: | 2023-06-30 | Release date: | 2024-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
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8TC8
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![BU of 8tc8 by Molmil](/molmil-images/mine/8tc8) | Human asparaginyl-tRNA synthetase bound to adenosine 5'-sulfamate | Descriptor: | 5'-O-[N-(L-ASPARAGINYL)SULFAMOYL]ADENOSINE, Asparagine--tRNA ligase, cytoplasmic, ... | Authors: | Dogovski, C, Metcalfe, R.D, Xie, S.C, Morton, C.J, Tilley, L, Griffin, M.D.W. | Deposit date: | 2023-06-30 | Release date: | 2024-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nat Commun, 15, 2024
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