7VLG

Crystal structure of Zika NS2B-NS3 protease with compound MI2201

Summary for 7VLG

Entry DOI	10.2210/pdb7vlg/pdb
Descriptor	Serine protease subunit NS2B, NS3 protease, SULFATE ION, ... (5 entities in total)
Functional Keywords	ns3 protease, viral protein
Biological source	Zika virus (ZIKV) More
Total number of polymer chains	2
Total formula weight	25671.90
Authors	Quek, J.P. (deposition date: 2021-10-02, release date: 2022-08-10, Last modification date: 2023-11-29)
Primary citation	Huber, S.,Braun, N.J.,Schmacke, L.C.,Quek, J.P.,Murra, R.,Bender, D.,Hildt, E.,Luo, D.,Heine, A.,Steinmetzer, T. Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors. J.Med.Chem., 65:6555-6572, 2022 Cited by PubMed: 35475620 DOI: 10.1021/acs.jmedchem.1c01860 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.771 Å)

Structure validation