2G1Q

crystal structure of KSP in complex with inhibitor 9h

Summary for 2G1Q

• Entry DOI: 10.2210/pdb2g1q/pdb
• Descriptor: Kinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: ksp, ksp-inhibitor complex, cell cycle
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P52732
• Total number of polymer chains: 2
• Total formula weight: 83787.05

Authors

Yan, Y. (deposition date: 2006-02-14, release date: 2006-10-03, Last modification date: 2024-02-14)

• Primary citation: Cox, C.D.,Torrent, M.,Breslin, M.J.,Mariano, B.J.,Whitman, D.B.,Coleman, P.J.,Buser, C.A.,Walsh, E.S.,Hamilton, K.,Schaber, M.D.,Lobell, R.B.,Tao, W.,South, V.J.,Kohl, N.E.,Yan, Y.,Kuo, L.C.,Prueksaritanont, T.,Slaughter, D.E.,Li, C.,Mahan, E.,Lu, B.,Hartman, G.D.; Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.; Bioorg.Med.Chem.Lett., 16:3175-3179, 2006; PubMed: 16603356; DOI: 10.1016/j.bmcl.2006.03.040

Experimental method

X-RAY DIFFRACTION (2.51 Å)