1BMA

BENZYL METHYL AMINIMIDE INHIBITOR COMPLEXED TO PORCINE PANCREATIC ELASTASE

Summary for 1BMA

Entry DOI	10.2210/pdb1bma/pdb
Related PRD ID	PRD_000358
Descriptor	Chymotrypsin-like elastase family member 1, CALCIUM ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	serine protease, metal-binding, protease, secreted, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Sus scrofa (pigs,swine,wild boar)
Cellular location	Secreted: P00772
Total number of polymer chains	1
Total formula weight	26585.77
Authors	Peisach, E.,Casebier, D.,Gallion, S.L.,Furth, P.,Petsko, G.A.,Hogan Jr., J.C.,Ringe, D. (deposition date: 1995-05-01, release date: 1995-12-07, Last modification date: 2024-10-23)
Primary citation	Peisach, E.,Casebier, D.,Gallion, S.L.,Furth, P.,Petsko, G.A.,Hogan Jr., J.C.,Ringe, D. Interaction of a peptidomimetic aminimide inhibitor with elastase. Science, 269:66-69, 1995 Cited by PubMed Abstract: The crystal structure of an aminimide analog of a dipeptide inhibitor of porcine pancreatic elastase bound to its target serine protease has been solved. The peptidomimetic molecule binds in the same fashion as the class of dipeptides from which it was derived, making similar interactions with the subsites on the elastase surface. Because aminimides are readily synthesized from a wide variety of starting materials, they form the basis for a combinatorial chemistry approach to rational drug design. PubMed: 7604279 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation