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2FL2

crystal structure of KSP in complex with inhibitor 19

Summary for 2FL2
Entry DOI10.2210/pdb2fl2/pdb
Related2FKY 2FL6
DescriptorKinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywordsksp, ksp-inhibitor complex, cell cycle
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P52732
Total number of polymer chains2
Total formula weight83460.57
Authors
Yan, Y. (deposition date: 2006-01-05, release date: 2006-02-07, Last modification date: 2024-02-14)
Primary citationFraley, M.E.,Garbaccio, R.M.,Arrington, K.L.,Hoffman, W.F.,Tasber, E.S.,Coleman, P.J.,Buser, C.A.,Walsh, E.S.,Hamilton, K.,Fernandes, C.,Schaber, M.D.,Lobell, R.B.,Tao, W.,South, V.J.,Yan, Y.,Kuo, L.C.,Prueksaritanont, T.,Shu, C.,Torrent, M.,Heimbrook, D.C.,Kohl, N.E.,Huber, H.E.,Hartman, G.D.
Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.
Bioorg.Med.Chem.Lett., 16:1775-1779, 2006
Cited by
PubMed: 16439123
DOI: 10.1016/j.bmcl.2006.01.030
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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