1C6Y

ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP.

Summary for 1C6Y

Entry DOI	10.2210/pdb1c6y/pdb
Related	1c6x 1c6z 1c70
Descriptor	PROTEIN (PROTEASE), N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE (3 entities in total)
Functional Keywords	hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22217.14
Authors	Munshi, S. (deposition date: 1999-12-28, release date: 2000-12-28, Last modification date: 2023-12-27)
Primary citation	Munshi, S.,Chen, Z.,Yan, Y.,Li, Y.,Olsen, D.B.,Schock, H.B.,Galvin, B.B.,Dorsey, B.,Kuo, L.C. An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease. Acta Crystallogr.,Sect.D, 56:381-388, 2000 Cited by PubMed: 10739910 DOI: 10.1107/S0907444900000469 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation