8TUB

HLA B7:02 with HPNGYKSLSTL

Summary for 8TUB

• Entry DOI: 10.2210/pdb8tub/pdb
• Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, B-7 alpha chain, HIS-PRO-ASN-GLY-TYR-LYS-SER-LEU-SER-THR-LEU, ... (6 entities in total)
• Functional Keywords: hla-b7 hla b7:02 mhc influenza b nucleoprotein, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 180192.67

Authors

Littler, D.R.,Rossjohn, J.,Chaurasia, P.,Petersen, J. (deposition date: 2023-08-16, release date: 2024-03-13, Last modification date: 2024-10-16)

Primary citation

Menon, T.,Illing, P.T.,Chaurasia, P.,McQuilten, H.A.,Shepherd, C.,Rowntree, L.C.,Petersen, J.,Littler, D.R.,Khuu, G.,Huang, Z.,Allen, L.F.,Rockman, S.,Crowe, J.,Flanagan, K.L.,Wakim, L.M.,Nguyen, T.H.O.,Mifsud, N.A.,Rossjohn, J.,Purcell, A.W.,van de Sandt, C.E.,Kedzierska, K.
CD8 + T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age.
Nat Commun, 15:3387-3387, 2024

PubMed Abstract: Influenza B viruses (IBVs) cause substantive morbidity and mortality, and yet immunity towards IBVs remains understudied. CD8 T-cells provide broadly cross-reactive immunity and alleviate disease severity by recognizing conserved epitopes. Despite the IBV burden, only 18 IBV-specific T-cell epitopes restricted by 5 HLAs have been identified currently. A broader array of conserved IBV T-cell epitopes is needed to develop effective cross-reactive T-cell based IBV vaccines. Here we identify 9 highly conserved IBV CD8 T-cell epitopes restricted to HLA-B*07:02, HLA-B*08:01 and HLA-B*35:01. Memory IBV-specific tetramerCD8 T-cells are present within blood and tissues. Frequencies of IBV-specific CD8 T-cells decline with age, but maintain a central memory phenotype. HLA-B*07:02 and HLA-B*08:01-restricted NP epitope-specific T-cells have distinct T-cell receptor repertoires. We provide structural basis for the IBV HLA-B*07:02-restricted NS1 (11-mer) and HLA-B*07:02-restricted NP epitope presentation. Our study increases the number of IBV CD8 T-cell epitopes, and defines IBV-specific CD8 T-cells at cellular and molecular levels, across tissues and age.

PubMed: 38684663
DOI: 10.1038/s41467-024-47576-y

Experimental method

X-RAY DIFFRACTION (2.4 Å)