8TUB

HLA B7:02 with HPNGYKSLSTL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0001913	biological_process	T cell mediated cytotoxicity
A	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
A	0002237	biological_process	response to molecule of bacterial origin
A	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
A	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
A	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
A	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
A	0002726	biological_process	positive regulation of T cell cytokine production
A	0005198	molecular_function	structural molecule activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005765	cellular_component	lysosomal membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006955	biological_process	immune response
A	0007608	biological_process	sensory perception of smell
A	0007611	biological_process	learning or memory
A	0009897	cellular_component	external side of plasma membrane
A	0009986	cellular_component	cell surface
A	0010977	biological_process	negative regulation of neuron projection development
A	0012507	cellular_component	ER to Golgi transport vesicle membrane
A	0016020	cellular_component	membrane
A	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
A	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
A	0023026	molecular_function	MHC class II protein complex binding
A	0030670	cellular_component	phagocytic vesicle membrane
A	0031901	cellular_component	early endosome membrane
A	0031902	cellular_component	late endosome membrane
A	0031905	cellular_component	early endosome lumen
A	0032092	biological_process	positive regulation of protein binding
A	0033077	biological_process	T cell differentiation in thymus
A	0034756	biological_process	regulation of iron ion transport
A	0035580	cellular_component	specific granule lumen
A	0042026	biological_process	protein refolding
A	0042605	molecular_function	peptide antigen binding
A	0042612	cellular_component	MHC class I protein complex
A	0042613	cellular_component	MHC class II protein complex
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0042824	cellular_component	MHC class I peptide loading complex
A	0045646	biological_process	regulation of erythrocyte differentiation
A	0048260	biological_process	positive regulation of receptor-mediated endocytosis
A	0050680	biological_process	negative regulation of epithelial cell proliferation
A	0050768	biological_process	negative regulation of neurogenesis
A	0050778	biological_process	positive regulation of immune response
A	0050870	biological_process	positive regulation of T cell activation
A	0051289	biological_process	protein homotetramerization
A	0055038	cellular_component	recycling endosome membrane
A	0060586	biological_process	multicellular organismal-level iron ion homeostasis
A	0070062	cellular_component	extracellular exosome
A	0071281	biological_process	cellular response to iron ion
A	0071283	biological_process	cellular response to iron(III) ion
A	0071316	biological_process	cellular response to nicotine
A	1900121	biological_process	negative regulation of receptor binding
A	1900122	biological_process	positive regulation of receptor binding
A	1904434	biological_process	positive regulation of ferrous iron binding
A	1904437	biological_process	positive regulation of transferrin receptor binding
A	1904724	cellular_component	tertiary granule lumen
A	1990000	biological_process	amyloid fibril formation
A	1990712	cellular_component	HFE-transferrin receptor complex
A	2000774	biological_process	positive regulation of cellular senescence
A	2000978	biological_process	negative regulation of forebrain neuron differentiation
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0032092	biological_process	positive regulation of protein binding
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1900121	biological_process	negative regulation of receptor binding
B	1900122	biological_process	positive regulation of receptor binding
B	1904434	biological_process	positive regulation of ferrous iron binding
B	1904437	biological_process	positive regulation of transferrin receptor binding
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
E	0000139	cellular_component	Golgi membrane
E	0001913	biological_process	T cell mediated cytotoxicity
E	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
E	0002237	biological_process	response to molecule of bacterial origin
E	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
E	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
E	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
E	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
E	0002726	biological_process	positive regulation of T cell cytokine production
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005765	cellular_component	lysosomal membrane
E	0005783	cellular_component	endoplasmic reticulum
E	0005788	cellular_component	endoplasmic reticulum lumen
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0007608	biological_process	sensory perception of smell
E	0007611	biological_process	learning or memory
E	0009897	cellular_component	external side of plasma membrane
E	0009986	cellular_component	cell surface
E	0010977	biological_process	negative regulation of neuron projection development
E	0012507	cellular_component	ER to Golgi transport vesicle membrane
E	0016020	cellular_component	membrane
E	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
E	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
E	0023026	molecular_function	MHC class II protein complex binding
E	0030670	cellular_component	phagocytic vesicle membrane
E	0031901	cellular_component	early endosome membrane
E	0031902	cellular_component	late endosome membrane
E	0031905	cellular_component	early endosome lumen
E	0032092	biological_process	positive regulation of protein binding
E	0033077	biological_process	T cell differentiation in thymus
E	0034756	biological_process	regulation of iron ion transport
E	0035580	cellular_component	specific granule lumen
E	0042026	biological_process	protein refolding
E	0042605	molecular_function	peptide antigen binding
E	0042612	cellular_component	MHC class I protein complex
E	0042613	cellular_component	MHC class II protein complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042824	cellular_component	MHC class I peptide loading complex
E	0045646	biological_process	regulation of erythrocyte differentiation
E	0048260	biological_process	positive regulation of receptor-mediated endocytosis
E	0050680	biological_process	negative regulation of epithelial cell proliferation
E	0050768	biological_process	negative regulation of neurogenesis
E	0050778	biological_process	positive regulation of immune response
E	0050870	biological_process	positive regulation of T cell activation
E	0051289	biological_process	protein homotetramerization
E	0055038	cellular_component	recycling endosome membrane
E	0060586	biological_process	multicellular organismal-level iron ion homeostasis
E	0070062	cellular_component	extracellular exosome
E	0071281	biological_process	cellular response to iron ion
E	0071283	biological_process	cellular response to iron(III) ion
E	0071316	biological_process	cellular response to nicotine
E	1900121	biological_process	negative regulation of receptor binding
E	1900122	biological_process	positive regulation of receptor binding
E	1904434	biological_process	positive regulation of ferrous iron binding
E	1904437	biological_process	positive regulation of transferrin receptor binding
E	1904724	cellular_component	tertiary granule lumen
E	1990000	biological_process	amyloid fibril formation
E	1990712	cellular_component	HFE-transferrin receptor complex
E	2000774	biological_process	positive regulation of cellular senescence
E	2000978	biological_process	negative regulation of forebrain neuron differentiation
I	0000139	cellular_component	Golgi membrane
I	0001913	biological_process	T cell mediated cytotoxicity
I	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
I	0002237	biological_process	response to molecule of bacterial origin
I	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
I	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
I	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
I	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
I	0002726	biological_process	positive regulation of T cell cytokine production
I	0005198	molecular_function	structural molecule activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005765	cellular_component	lysosomal membrane
I	0005783	cellular_component	endoplasmic reticulum
I	0005788	cellular_component	endoplasmic reticulum lumen
I	0005794	cellular_component	Golgi apparatus
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0005925	cellular_component	focal adhesion
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006955	biological_process	immune response
I	0007608	biological_process	sensory perception of smell
I	0007611	biological_process	learning or memory
I	0009897	cellular_component	external side of plasma membrane
I	0009986	cellular_component	cell surface
I	0010977	biological_process	negative regulation of neuron projection development
I	0012507	cellular_component	ER to Golgi transport vesicle membrane
I	0016020	cellular_component	membrane
I	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
I	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
I	0023026	molecular_function	MHC class II protein complex binding
I	0030670	cellular_component	phagocytic vesicle membrane
I	0031901	cellular_component	early endosome membrane
I	0031902	cellular_component	late endosome membrane
I	0031905	cellular_component	early endosome lumen
I	0032092	biological_process	positive regulation of protein binding
I	0033077	biological_process	T cell differentiation in thymus
I	0034756	biological_process	regulation of iron ion transport
I	0035580	cellular_component	specific granule lumen
I	0042026	biological_process	protein refolding
I	0042605	molecular_function	peptide antigen binding
I	0042612	cellular_component	MHC class I protein complex
I	0042613	cellular_component	MHC class II protein complex
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0042824	cellular_component	MHC class I peptide loading complex
I	0045646	biological_process	regulation of erythrocyte differentiation
I	0048260	biological_process	positive regulation of receptor-mediated endocytosis
I	0050680	biological_process	negative regulation of epithelial cell proliferation
I	0050768	biological_process	negative regulation of neurogenesis
I	0050778	biological_process	positive regulation of immune response
I	0050870	biological_process	positive regulation of T cell activation
I	0051289	biological_process	protein homotetramerization
I	0055038	cellular_component	recycling endosome membrane
I	0060586	biological_process	multicellular organismal-level iron ion homeostasis
I	0070062	cellular_component	extracellular exosome
I	0071281	biological_process	cellular response to iron ion
I	0071283	biological_process	cellular response to iron(III) ion
I	0071316	biological_process	cellular response to nicotine
I	1900121	biological_process	negative regulation of receptor binding
I	1900122	biological_process	positive regulation of receptor binding
I	1904434	biological_process	positive regulation of ferrous iron binding
I	1904437	biological_process	positive regulation of transferrin receptor binding
I	1904724	cellular_component	tertiary granule lumen
I	1990000	biological_process	amyloid fibril formation
I	1990712	cellular_component	HFE-transferrin receptor complex
I	2000774	biological_process	positive regulation of cellular senescence
I	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH

Chain	Residue	Details
F	TYR257-HIS263
A	TYR78-HIS84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	BINDING: BINDING => ECO:0000269|PubMed:25808313

Chain	Residue	Details
F	ASN63
C	THR143
C	LYS146
C	GLU152
C	TYR159
C	TYR171
G	ASN63
G	TYR84
G	THR143
G	LYS146
G	GLU152
F	TYR84
G	TYR159
G	TYR171
J	ASN63
J	TYR84
J	THR143
J	LYS146
J	GLU152
J	TYR159
J	TYR171
F	THR143
F	LYS146
F	GLU152
F	TYR159
F	TYR171
C	ASN63
C	TYR84

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
F	ASN86
C	ASN86
G	ASN86
J	ASN86

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443

Chain	Residue	Details
A	LYS19
B	LYS58
B	LYS91
B	LYS94
E	LYS19
E	LYS41
E	LYS48
E	LYS58
E	LYS91
E	LYS94
I	LYS19
A	LYS41
I	LYS41
I	LYS48
I	LYS58
I	LYS91
I	LYS94
A	LYS48
A	LYS58
A	LYS91
A	LYS94
B	LYS19
B	LYS41
B	LYS48

---