1JAN
| COMPLEX OF PRO-LEU-GLY-HYDROXYLAMINE WITH THE CATALYTIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (PHE79 FORM) | Descriptor: | CALCIUM ION, MATRIX METALLO PROTEINASE-8 (PHE79 FORM), PRO-LEU-GLY-HYDROXYLAMINE INHIBITOR, ... | Authors: | Reinemer, P, Grams, F, Huber, R, Kleine, T, Schnierer, S, Pieper, M, Tschesche, H, Bode, W. | Deposit date: | 1996-03-11 | Release date: | 1996-07-11 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study. FEBS Lett., 338, 1994
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7NVQ
| Aerosol-soaked human cdk2 crystals with Staurosporine | Descriptor: | 1,2-ETHANEDIOL, Cyclin-dependent kinase 2, STAUROSPORINE | Authors: | Ross, B, Huber, R. | Deposit date: | 2021-03-15 | Release date: | 2021-06-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Aerosol-based ligand soaking of reservoir-free protein crystals. J.Appl.Crystallogr., 54, 2021
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5JDW
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4CTS
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6EOP
| DPP8 - SLRFLYEG, space group 20 | Descriptor: | CALCIUM ION, CITRATE ANION, Dipeptidyl peptidase 8, ... | Authors: | Ross, B.R, Huber, R. | Deposit date: | 2017-10-10 | Release date: | 2018-02-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6EOO
| DPP8 - Apo, space group 20 | Descriptor: | Dipeptidyl peptidase 8 | Authors: | Ross, B.R, Huber, R. | Deposit date: | 2017-10-10 | Release date: | 2018-02-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6EOR
| DPP9 - 1G244 | Descriptor: | (2~{S})-2-azanyl-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(1,3-dihydroisoindol-2-yl)butane-1,4-dione, Dipeptidyl peptidase 9 | Authors: | Ross, B.R, Huber, R. | Deposit date: | 2017-10-10 | Release date: | 2018-02-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6EOS
| DPP8 - Apo, space group 19 | Descriptor: | Dipeptidyl peptidase 8 | Authors: | Ross, B.R, Huber, R. | Deposit date: | 2017-10-10 | Release date: | 2018-02-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6EOQ
| DPP9 - Apo | Descriptor: | Dipeptidyl peptidase 9 | Authors: | Ross, B.R, Huber, R. | Deposit date: | 2017-10-10 | Release date: | 2018-02-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6EOT
| DPP8 - SLRFLYEG, space group 19 | Descriptor: | Dipeptidyl peptidase 8, SER-LEU-ARG-PHE-LEU-TYR-GLU-GLY | Authors: | Ross, B.R, Huber, R. | Deposit date: | 2017-10-10 | Release date: | 2018-02-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6Z6F
| HDAC-PC | Descriptor: | HDA1 complex subunit 2, HDA1 complex subunit 3,HDA1 complex subunit 3, Histone deacetylase HDA1, ... | Authors: | Lee, J.-H, Bollschweiler, D, Schaefer, T, Huber, R. | Deposit date: | 2020-05-28 | Release date: | 2021-02-17 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Sci Adv, 7, 2021
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6Z6O
| HDAC-TC | Descriptor: | HDA1 complex subunit 2, HDA1 complex subunit 3,HDA1 complex subunit 3, Histone deacetylase HDA1, ... | Authors: | Lee, J.-H, Bollschweiler, D, Schaefer, T, Huber, R. | Deposit date: | 2020-05-28 | Release date: | 2021-02-17 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Sci Adv, 7, 2021
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6Z6H
| HDAC-DC | Descriptor: | HDA1 complex subunit 2, HDA1 complex subunit 3,HDA1 complex subunit 3, Histone deacetylase HDA1, ... | Authors: | Lee, J.-H, Bollschweiler, D, Schaefer, T, Huber, R. | Deposit date: | 2020-05-28 | Release date: | 2021-02-17 | Method: | ELECTRON MICROSCOPY (8.55 Å) | Cite: | Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Sci Adv, 7, 2021
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6Z6P
| HDAC-PC-Nuc | Descriptor: | DNA (145-MER), HDA1 complex subunit 2, HDA1 complex subunit 3,HDA1 complex subunit 3, ... | Authors: | Lee, J.-H, Bollschweiler, D, Schaefer, T, Huber, R. | Deposit date: | 2020-05-28 | Release date: | 2021-02-17 | Method: | ELECTRON MICROSCOPY (4.43 Å) | Cite: | Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Sci Adv, 7, 2021
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6JDW
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1KLI
| Cofactor-and substrate-assisted activation of factor VIIa | Descriptor: | BENZAMIDINE, CALCIUM ION, GLYCEROL, ... | Authors: | Sichler, K, Banner, D.W, D'Arcy, A, Hopfner, K.P, Huber, R, Bode, W, Kresse, G.B, Kopetzki, E, Brandstetter, H. | Deposit date: | 2001-12-12 | Release date: | 2002-09-18 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Crystal Structure of Uninhibited Factor VIIa Link its Cofactor and Substrate-assisted Activation to Specific Interactions J.Mol.Biol., 322, 2002
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1KFX
| Crystal Structure of Human m-Calpain Form I | Descriptor: | M-CALPAIN LARGE SUBUNIT, M-CALPAIN SMALL SUBUNIT | Authors: | Strobl, S, Fernandez-Catalan, C, Braun, M, Huber, R, Masumoto, H, Nakagawa, K, Irie, A, Sorimachi, H, Bourenkow, G, Bartunik, H, Suzuki, K, Bode, W. | Deposit date: | 2001-11-23 | Release date: | 2001-12-07 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. Proc.Natl.Acad.Sci.USA, 97, 2000
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5JXJ
| Structure of the proprotein convertase furin complexed to meta-guanidinomethyl-Phac-RVR-Amba in presence of EDTA | Descriptor: | 2UC-ARG-VAL-ARG-00S, CALCIUM ION, CHLORIDE ION, ... | Authors: | Dahms, S.O, Arciniega, M, Steinmetzer, T, Huber, R, Than, M.E. | Deposit date: | 2016-05-13 | Release date: | 2016-10-05 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
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5JXI
| Structure of the unliganded form of the proprotein convertase furin in presence of EDTA. | Descriptor: | CALCIUM ION, CHLORIDE ION, Furin, ... | Authors: | Dahms, S.O, Arciniega, M, Steinmetzer, T, Huber, R, Than, M.E. | Deposit date: | 2016-05-13 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
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5JXG
| Structure of the unliganded form of the proprotein convertase furin. | Descriptor: | CALCIUM ION, CHLORIDE ION, Furin, ... | Authors: | Dahms, S.O, Arciniega, M, Steinmetzer, T, Huber, R, Than, M.E. | Deposit date: | 2016-05-13 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
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5JXH
| Structure the proprotein convertase furin in complex with meta-guanidinomethyl-Phac-RVR-Amba at 2.0 Angstrom resolution. | Descriptor: | 2UC-ARG-VAL-ARG-00S, CALCIUM ION, CHLORIDE ION, ... | Authors: | Dahms, S.O, Arciniega, M, Steinmetzer, T, Huber, R, Than, M.E. | Deposit date: | 2016-05-13 | Release date: | 2016-10-05 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism. Proc.Natl.Acad.Sci.USA, 113, 2016
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4AZU
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1JFD
| STRUCTURE OF INORGANIC PYROPHOSPHATASE | Descriptor: | INORGANIC PYROPHOSPHATASE, SULFATE ION | Authors: | Oganesyan, V, Avaeva, S.M, Huber, R, Harutyunyan, E.H. | Deposit date: | 1997-05-31 | Release date: | 1997-12-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of Escherichia coli inorganic pyrophosphatase complexed with SO4(2-). Ligand-induced molecular asymmetry. FEBS Lett., 410, 1997
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1ASO
| X-RAY STRUCTURES AND MECHANISTIC IMPLICATIONS OF THREE FUNCTIONAL DERIVATIVES OF ASCORBATE OXIDASE FROM ZUCCHINI: REDUCED-, PEROXIDE-, AND AZIDE-FORMS | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ASCORBATE OXIDASE, COPPER (II) ION, ... | Authors: | Messerschmidt, A, Luecke, H, Huber, R. | Deposit date: | 1992-11-25 | Release date: | 1994-01-31 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | X-ray structures and mechanistic implications of three functional derivatives of ascorbate oxidase from zucchini. Reduced, peroxide and azide forms. J.Mol.Biol., 230, 1993
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1A9C
| GTP CYCLOHYDROLASE I (C110S MUTANT) IN COMPLEX WITH GTP | Descriptor: | GTP CYCLOHYDROLASE I, GUANOSINE-5'-TRIPHOSPHATE | Authors: | Auerbach, G, Nar, H, Bracher, A, Bacher, A, Huber, R. | Deposit date: | 1998-04-04 | Release date: | 1999-05-11 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | GTP Cyclohydrolase I in Complex with GTP at 2.1 A Resolution To be Published
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