1KLI

Cofactor-and substrate-assisted activation of factor VIIa

Summary for 1KLI

• Entry DOI: 10.2210/pdb1kli/pdb
• Related: 1KLJ
• Descriptor: factor VIIa, SULFATE ION, CALCIUM ION, ... (7 entities in total)
• Functional Keywords: extrinsic coagulation pathway, serine protease activation, rational drug design, substrate-assisted catalysis, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P08709 P08709
• Total number of polymer chains: 2
• Total formula weight: 36350.37

Authors

Sichler, K.,Banner, D.W.,D'Arcy, A.,Hopfner, K.P.,Huber, R.,Bode, W.,Kresse, G.B.,Kopetzki, E.,Brandstetter, H. (deposition date: 2001-12-12, release date: 2002-09-18, Last modification date: 2011-07-13)

• Primary citation: Sichler, K.,Banner, D.W.,D'Arcy, A.,Hopfner, K.P.,Huber, R.,Bode, W.,Kresse, G.B.,Kopetzki, E.,Brandstetter, H.; Crystal Structure of Uninhibited Factor VIIa Link its Cofactor and Substrate-assisted Activation to Specific Interactions; J.Mol.Biol., 322:591-603, 2002; PubMed: 12225752; DOI: 10.1016/S0022-2836(02)00747-7

Experimental method

X-RAY DIFFRACTION (1.69 Å)