1KLI

Cofactor-and substrate-assisted activation of factor VIIa

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 H 400

Chain	Residue
H	MET164
H	THR165
H	ARG230
H	HOH708
H	HOH782

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 H 401

Chain	Residue
H	BEN300
H	HOH756
H	HIS57
H	LYS192
H	GLY193
H	SER195

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 H 402

Chain	Residue
H	SER170
H	HIS224
H	PHE225
H	VAL227
H	HOH501

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 H 403

Chain	Residue
H	SER244
H	GLU245
H	HOH675
H	HOH686
L	HOH656

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA H 900

Chain	Residue
H	GLU70
H	ASP72
H	GLU75
H	GLU80
H	HOH551
H	HOH646

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE BEN H 300

Chain	Residue
H	ASP189
H	SER190
H	SER195
H	VAL213
H	SER214
H	TRP215
H	GLY219
H	GLY226
H	SO4401
H	HOH647

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL H 1000

Chain	Residue
H	PHE59
H	TRP61
H	ILE90
H	PRO96
H	HOH562
H	HOH631

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
H	VAL53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA

Chain	Residue	Details
H	ASP189-ALA200

---

site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC

Chain	Residue	Details
L	CYS112-CYS127

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	41
Details	Domain: {"description":"EGF-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	239
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19167329","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3264725","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	HIS57

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	SER195
H	GLY196

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	SER195
H	GLY193

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	HIS57

---

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	HIS57
H	GLY196

---

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	GLY193
H	HIS57

---