1KFX

Crystal Structure of Human m-Calpain Form I

Summary for 1KFX

Related1KFU
DescriptorM-CALPAIN LARGE SUBUNIT, M-CALPAIN SMALL SUBUNIT (3 entities in total)
Functional Keywordsregulation, papain-like, thiol-protease, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P17655
Cytoplasm (By similarity) P04632
Total number of polymer chains2
Total molecular weight101231.88
Authors
Strobl, S.,Fernandez-Catalan, C.,Braun, M.,Huber, R.,Masumoto, H.,Nakagawa, K.,Irie, A.,Sorimachi, H.,Bourenkow, G.,Bartunik, H.,Suzuki, K.,Bode, W. (deposition date: 2001-11-23, release date: 2001-12-07, Last modification date: 2012-05-02)
Primary citation
Strobl, S.,Fernandez-Catalan, C.,Braun, M.,Huber, R.,Masumoto, H.,Nakagawa, K.,Irie, A.,Sorimachi, H.,Bourenkow, G.,Bartunik, H.,Suzuki, K.,Bode, W.
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
Proc.Natl.Acad.Sci.USA, 97:588-592, 2000
PubMed: 10639123 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.97.2.588
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.15 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers639.6%13.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
168889
PDB entries from 2020-09-16