1KFX

Crystal Structure of Human m-Calpain Form I

Summary for 1KFX

• Entry DOI: 10.2210/pdb1kfx/pdb
• Related: 1KFU
• Descriptor: M-CALPAIN LARGE SUBUNIT, M-CALPAIN SMALL SUBUNIT (3 entities in total)
• Functional Keywords: regulation, papain-like, thiol-protease, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P17655; Cytoplasm (By similarity): P04632
• Total number of polymer chains: 2
• Total formula weight: 101231.88

Authors

Strobl, S.,Fernandez-Catalan, C.,Braun, M.,Huber, R.,Masumoto, H.,Nakagawa, K.,Irie, A.,Sorimachi, H.,Bourenkow, G.,Bartunik, H.,Suzuki, K.,Bode, W. (deposition date: 2001-11-23, release date: 2001-12-07, Last modification date: 2023-08-16)

• Primary citation: Strobl, S.,Fernandez-Catalan, C.,Braun, M.,Huber, R.,Masumoto, H.,Nakagawa, K.,Irie, A.,Sorimachi, H.,Bourenkow, G.,Bartunik, H.,Suzuki, K.,Bode, W.; The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.; Proc.Natl.Acad.Sci.USA, 97:588-592, 2000; PubMed: 10639123; DOI: 10.1073/pnas.97.2.588

Experimental method

X-RAY DIFFRACTION (3.15 Å)