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2PWL
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BU of 2pwl by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549H Mutation Responsible for Crouzon Syndrome.
Descriptor: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-11
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
5XTZ
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BU of 5xtz by Molmil
Crystal structure of GAS41 YEATS bound to H3K27ac peptide
Descriptor: ACETATE ION, THR-LYS-ALA-ALA-ARG-ALY-SER-ALA-PRO-ALA, YEATS domain-containing protein 4
Authors:Li, H.T, Zhao, D.
Deposit date:2017-06-21
Release date:2018-06-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.105 Å)
Cite:Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity.
Cell Discov, 4, 2018
2PVF
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BU of 2pvf by Molmil
Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide
Descriptor: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-09
Release date:2007-09-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PZ5
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BU of 2pz5 by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome
Descriptor: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-17
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PSQ
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BU of 2psq by Molmil
Crystal Structure of Unphosphorylated Unactivated Wild Type FGF Receptor 2 (FGFR2) Kinase Domain
Descriptor: Fibroblast growth factor receptor 2, SULFATE ION
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-07
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PVY
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BU of 2pvy by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome.
Descriptor: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-10
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PZR
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BU of 2pzr by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K641R Mutation Responsible for Pfeiffer Syndrome
Descriptor: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-18
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PY3
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BU of 2py3 by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation Responsible for Pfeiffer Syndrome
Descriptor: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-15
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2Q0B
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BU of 2q0b by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565A Mutation Responsible for Pfeiffer Syndrome
Descriptor: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-21
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PZP
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BU of 2pzp by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible for Crouzon Syndrome
Descriptor: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Chen, H, Mohammadi, M.
Deposit date:2007-05-18
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2QJ0
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BU of 2qj0 by Molmil
Structure of the yeast U-box-containing ubiquitin ligase Ufd2p
Descriptor: Ubiquitin conjugation factor E4
Authors:Tu, D, Brunger, A.T.
Deposit date:2007-07-06
Release date:2007-09-18
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Inaugural Article: Structure and function of the yeast U-box-containing ubiquitin ligase Ufd2p.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2QIZ
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BU of 2qiz by Molmil
Structure of the yeast U-box-containing ubiquitin ligase Ufd2p
Descriptor: POTASSIUM ION, Ubiquitin conjugation factor E4
Authors:Tu, D, Brunger, A.T.
Deposit date:2007-07-06
Release date:2007-09-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Inaugural Article: Structure and function of the yeast U-box-containing ubiquitin ligase Ufd2p.
Proc.Natl.Acad.Sci.Usa, 104, 2007
6OQ4
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BU of 6oq4 by Molmil
Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi1
Descriptor: 2-{(Z)-[(2-hydroxynaphthalen-1-yl)methylidene]amino}-N-[(1S)-1-phenylethyl]benzamide, Krev interaction trapped protein 1, MAGNESIUM ION, ...
Authors:Gingras, A.R.
Deposit date:2019-04-25
Release date:2020-06-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.754 Å)
Cite:Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells
Faseb Bioadv, 2021
6OQ3
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BU of 6oq3 by Molmil
Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi2
Descriptor: 2-hydroxynaphthalene-1-carbaldehyde, Krev interaction trapped protein 1, MAGNESIUM ION, ...
Authors:Gingras, A.R.
Deposit date:2019-04-25
Release date:2020-06-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells
Faseb Bioadv, 2021
6P4Y
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BU of 6p4y by Molmil
Crystal Structure of anti-IL-7Ralpha 4A10 Fab
Descriptor: 4A10 Fab heavy chain, 4A10 Fab light chain
Authors:Walsh, S.T.R, Kashi, L, Kohnhorst, C.L.
Deposit date:2019-05-29
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Leukemia, 34, 2020
6P67
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BU of 6p67 by Molmil
Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha 2B8 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-IL-7R 2B8 Fab heavy chain, ...
Authors:Walsh, S.T.R, Kashi, L, Kohnhorst, C.L.
Deposit date:2019-06-03
Release date:2019-09-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Leukemia, 34, 2020
6P50
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BU of 6p50 by Molmil
Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha Fab 4A10
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-7 receptor subunit alpha, anti-IL-7R 4A10 Fab heavy chain, ...
Authors:Walsh, S.T.R, Kashi, L, Kohnhorst, C.L.
Deposit date:2019-05-29
Release date:2019-09-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.
Leukemia, 34, 2020
6RB7
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BU of 6rb7 by Molmil
Ruminococcus gnavus sialic acid aldolase catalytic lysine mutant
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BICINE, DI(HYDROXYETHYL)ETHER, ...
Authors:Owen, C.D, Bell, A, Juge, N, Walsh, M.A.
Deposit date:2019-04-09
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut.
Nat Microbiol, 4, 2019
6RAB
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BU of 6rab by Molmil
Ruminococcus gnavus sialic acid aldolase Wild Type
Descriptor: Putative N-acetylneuraminate lyase
Authors:Owen, C.D, Bell, A, Juge, N, Walsh, M.A.
Deposit date:2019-04-05
Release date:2019-09-25
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut.
Nat Microbiol, 4, 2019
6RD1
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BU of 6rd1 by Molmil
Ruminococcus gnavus sialic acid aldolase catalytic lysine mutant in complex with sialic acid
Descriptor: 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-2-ulosonic acid, Putative N-acetylneuraminate lyase
Authors:Owen, C.D, Bell, A, Juge, N, Walsh, M.A.
Deposit date:2019-04-12
Release date:2019-09-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut.
Nat Microbiol, 4, 2019
6DS6
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BU of 6ds6 by Molmil
Crystal structure of p300 ZZ domain in complex with histone H3 peptide
Descriptor: CHLORIDE ION, Histone H3 peptide-Histone acetyltransferase p300 Chimeric protein, ZINC ION
Authors:Zhang, Y, Kutateladze, T.G.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3.
Nat. Struct. Mol. Biol., 25, 2018
6E86
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BU of 6e86 by Molmil
Solution structure of ZZZ3 ZZ domain in complex with histone H3K4ac peptide
Descriptor: H3K4ac, ZINC ION, ZZ-type zinc finger-containing protein 3
Authors:Zhang, Y, Kutateladze, T.G.
Deposit date:2018-07-27
Release date:2018-09-19
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation.
Nat Commun, 9, 2018
7YJ3
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BU of 7yj3 by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with human ACE2 (local refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ...
Authors:Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F.
Deposit date:2022-07-19
Release date:2023-07-19
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants.
Nat Commun, 14, 2023
7YHW
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BU of 7yhw by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron BA.2.12.1 RBD in complex with human ACE2 (local refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F.
Deposit date:2022-07-14
Release date:2023-07-19
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants.
Nat Commun, 14, 2023
3OG4
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BU of 3og4 by Molmil
The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P21212
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin 28 receptor, alpha (Interferon, ...
Authors:Miknis, Z.J, Magracheva, E, Lei, W, Zdanov, A, Kotenko, S.V, Wlodawer, A.
Deposit date:2010-08-16
Release date:2010-10-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Crystal structure of the complex of human interferon-lambda1 with its high affinity receptor interferon-lambdaR1.
J.Mol.Biol., 404, 2010

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