6P50

Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha Fab 4A10

Summary for 6P50

Entry DOI	10.2210/pdb6p50/pdb
Descriptor	Interleukin-7 receptor subunit alpha, anti-IL-7R 4A10 Fab heavy chain, anti-IL-7R 4A10 Fab light chain, ... (4 entities in total)
Functional Keywords	interleukin-7 receptor extracellular dohmain, antibody 4a10 fab fragment, protein polymer, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	73878.69
Authors	Walsh, S.T.R.,Kashi, L.,Kohnhorst, C.L. (deposition date: 2019-05-29, release date: 2019-09-04, Last modification date: 2023-10-11)
Primary citation	Hixon, J.A.,Andrews, C.,Kashi, L.,Kohnhorst, C.L.,Senkevitch, E.,Czarra, K.,Barata, J.T.,Li, W.,Schneider, J.P.,Walsh, S.T.R.,Durum, S.K. New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models. Leukemia, 34:35-49, 2020 Cited by PubMed: 31439943 DOI: 10.1038/s41375-019-0531-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation