6P4Y

Crystal Structure of anti-IL-7Ralpha 4A10 Fab

Summary for 6P4Y

• Entry DOI: 10.2210/pdb6p4y/pdb
• Descriptor: 4A10 Fab heavy chain, 4A10 Fab light chain (3 entities in total)
• Functional Keywords: antibody 4a10 fab fragment, protein polymer, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 47966.46

Authors

Walsh, S.T.R.,Kashi, L.,Kohnhorst, C.L. (deposition date: 2019-05-29, release date: 2019-09-04, Last modification date: 2023-10-11)

• Primary citation: Hixon, J.A.,Andrews, C.,Kashi, L.,Kohnhorst, C.L.,Senkevitch, E.,Czarra, K.,Barata, J.T.,Li, W.,Schneider, J.P.,Walsh, S.T.R.,Durum, S.K.; New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models.; Leukemia, 34:35-49, 2020; PubMed: 31439943; DOI: 10.1038/s41375-019-0531-8

Experimental method

X-RAY DIFFRACTION (1.799 Å)