4R2Y
| Crystal structure of APC11 RING domain | Descriptor: | Anaphase-promoting complex subunit 11, ZINC ION | Authors: | Brown, N.G, Watson, E.R, Weissmann, F, Jarvis, M.A, Vanderlinden, R, Grace, C.R.R, Frye, J.J, Dube, P, Qiao, R, Petzold, G, Cho, S.E, Alsharif, O, Bao, J, Zheng, J, Nourse, A, Kurinov, I, Peters, J.M, Stark, H, Schulman, B.A. | Deposit date: | 2014-08-13 | Release date: | 2014-10-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.755 Å) | Cite: | Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly. Mol.Cell, 56, 2014
|
|
6FF4
| human Bact spliceosome core structure | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | Authors: | Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H. | Deposit date: | 2018-01-03 | Release date: | 2018-08-29 | Last modified: | 2020-10-07 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure and Conformational Dynamics of the Human Spliceosomal BactComplex. Cell, 172, 2018
|
|
6H55
| core of the human pyruvate dehydrogenase (E2) | Descriptor: | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial | Authors: | Haselbach, D, Prajapati, S, Tittmann, K, Stark, H. | Deposit date: | 2018-07-23 | Release date: | 2019-06-05 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters. Structure, 27, 2019
|
|
6H60
| pseudo-atomic structural model of the E3BP component of the human pyruvate dehydrogenase multienzyme complex | Descriptor: | Pyruvate dehydrogenase protein X component, mitochondrial | Authors: | Haselbach, D, Prajapati, S, Tittmann, K, Stark, H. | Deposit date: | 2018-07-25 | Release date: | 2019-06-05 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters. Structure, 27, 2019
|
|
2AGN
| Fitting of hepatitis C virus internal ribosome entry site domains into the 15 A Cryo-EM map of a HCV IRES-80S ribosome (H. sapiens) complex | Descriptor: | 6 nt A-RNA helix, HCV IRES DOMAIN II, HCV IRES IIIABC, ... | Authors: | Boehringer, D, Thermann, R, Ostareck-Lederer, A, Lewis, J.D, Stark, H. | Deposit date: | 2005-07-27 | Release date: | 2006-07-25 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (15 Å) | Cite: | Structure of the hepatitis C Virus IRES bound to the human 80S ribosome: remodeling of the HCV IRES Structure, 13, 2005
|
|
1ZAW
| Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form A | Descriptor: | 50S ribosomal protein L10, 50S ribosomal protein L7/L12 | Authors: | Diaconu, M, Kothe, U, Schluenzen, F, Fischer, N, Harms, J.M, Tonevitski, A.G, Stark, H, Rodnina, M.V, Wahl, M.C. | Deposit date: | 2005-04-07 | Release date: | 2005-07-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and GTPase Activation. Cell(Cambridge,Mass.), 121, 2005
|
|
1ZAX
| Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form B | Descriptor: | 50S ribosomal protein L10, 50S ribosomal protein L7/L12 | Authors: | Diaconu, M, Kothe, U, Schluenzen, F, Fischer, N, Harms, J.M, Tonevitski, A.G, Stark, H, Rodnina, M.V, Wahl, M.C. | Deposit date: | 2005-04-07 | Release date: | 2005-07-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and GTPase Activation. Cell(Cambridge,Mass.), 121, 2005
|
|
1ZAV
| Ribosomal Protein L10-L12(NTD) Complex, Space Group P21 | Descriptor: | 50S ribosomal protein L10, 50S ribosomal protein L7/L12 | Authors: | Diaconu, M, Kothe, U, Schluenzen, F, Fischer, N, Harms, J.M, Tonevitski, A.G, Stark, H, Rodnina, M.V, Wahl, M.C. | Deposit date: | 2005-04-07 | Release date: | 2005-07-12 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis for the Function of the Ribosomal L7/12 Stalk in Factor Binding and GTPase Activation. Cell(Cambridge,Mass.), 121, 2005
|
|
6Y50
| 5'domain of human 17S U2 snRNP | Descriptor: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ... | Authors: | Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H. | Deposit date: | 2020-02-24 | Release date: | 2020-07-01 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Molecular architecture of the human 17S U2 snRNP. Nature, 583, 2020
|
|
7ABG
| Human pre-Bact-1 spliceosome | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cell division cycle 5-like protein, ... | Authors: | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | Deposit date: | 2020-09-07 | Release date: | 2020-12-23 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (7.8 Å) | Cite: | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
|
|
7ABI
| Human pre-Bact-2 spliceosome | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Beta-catenin-like protein 1, ... | Authors: | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | Deposit date: | 2020-09-07 | Release date: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (8 Å) | Cite: | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
|
|
7ABH
| Human pre-Bact-2 spliceosome (SF3b/U2 snRNP portion) | Descriptor: | Cell division cycle 5-like protein, DNA/RNA-binding protein KIN17, MINX M3 pre-mRNA, ... | Authors: | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | Deposit date: | 2020-09-07 | Release date: | 2020-12-09 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
|
|
7ABF
| Human pre-Bact-1 spliceosome core structure | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | Deposit date: | 2020-09-07 | Release date: | 2020-12-09 | Last modified: | 2020-12-30 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
|
|
5AFI
| 2.9A Structure of E. coli ribosome-EF-TU complex by cs-corrected cryo-EM | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Fischer, N, Neumann, P, Konevega, A.L, Bock, L.V, Ficner, R, Rodnina, M.V, Stark, H. | Deposit date: | 2015-01-22 | Release date: | 2015-03-11 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of the E. coli ribosome-EF-Tu complex at <3 angstrom resolution by Cs-corrected cryo-EM. Nature, 520, 2015
|
|
7AAV
| Human pre-Bact-2 spliceosome core structure | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, D-chiro inositol hexakisphosphate, ... | Authors: | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | Deposit date: | 2020-09-04 | Release date: | 2020-12-09 | Last modified: | 2020-12-30 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
|
|
6QL6
| Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom | Descriptor: | FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ... | Authors: | Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. | Deposit date: | 2019-01-31 | Release date: | 2020-03-18 | Last modified: | 2020-04-08 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase. Cell, 180, 2020
|
|
6QL7
| Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 4.6 angstrom | Descriptor: | Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, Translation machinery-associated protein 17 | Authors: | Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. | Deposit date: | 2019-01-31 | Release date: | 2020-03-18 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (4.6 Å) | Cite: | Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase. Cell, 180, 2020
|
|
6QL9
| Structure of Fatty acid synthase complex from Saccharomyces cerevisiae at 2.9 Angstrom | Descriptor: | 1,2-ETHANEDIOL, 4'-PHOSPHOPANTETHEINE, ACETATE ION, ... | Authors: | Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. | Deposit date: | 2019-01-31 | Release date: | 2020-03-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase. Cell, 180, 2020
|
|
5KHU
| Model of human Anaphase-promoting complex/Cyclosome (APC15 deletion mutant), in complex with the Mitotic checkpoint complex (APC/C-CDC20-MCC) based on cryo EM data at 4.8 Angstrom resolution | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Yamaguchi, M, VanderLinden, R, Dube, P, Stark, H, Schulman, B. | Deposit date: | 2016-06-15 | Release date: | 2016-09-07 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation. Mol.Cell, 63, 2016
|
|
5KHR
| Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with the E2 UBE2C/UBCH10 poised for ubiquitin ligation to substrate (APC/C-CDC20-substrate-UBE2C) | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | VanderLinden, R, Yamaguchi, M, Dube, P, Haselbach, D, Stark, H, Schulman, B.A. | Deposit date: | 2016-06-15 | Release date: | 2016-08-24 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (6.1 Å) | Cite: | Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation. Mol.Cell, 63, 2016
|
|
8QPA
| Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | Deposit date: | 2023-10-01 | Release date: | 2024-05-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
|
|
8R0B
| Cryo-EM structure of the cross-exon pre-B+ATP complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | Deposit date: | 2023-10-31 | Release date: | 2024-05-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
|
|
8QPK
| Cryo-EM Structure of Pre-B+5'ss Complex (core part) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | Deposit date: | 2023-10-02 | Release date: | 2024-05-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
|
|
8R09
| Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | Deposit date: | 2023-10-31 | Release date: | 2024-05-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
|
|
8QP8
| Cryo-EM Structure of Pre-B Complex (core part) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Pre-mRNA-processing factor 6, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | Deposit date: | 2023-09-30 | Release date: | 2024-05-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
|
|