6OT5
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![BU of 6ot5 by Molmil](/molmil-images/mine/6ot5) | Structure of the TRPV3 K169A sensitized mutant in the presence of 2-APB at 3.6 A resolution | Descriptor: | 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 3,Transient receptor potential cation channel subfamily V member 3 | Authors: | Zubcevic, L, Borschel, W.F, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | Deposit date: | 2019-05-02 | Release date: | 2019-05-22 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Regulatory switch at the cytoplasmic interface controls TRPV channel gating. Elife, 8, 2019
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8TZ5
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8TZ3
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8TZ2
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8TZA
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8TZ7
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8TZD
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8TZ4
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![BU of 8tz4 by Molmil](/molmil-images/mine/8tz4) | Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with GS-441524, subset reconstruction | Descriptor: | (2~{R},3~{R},4~{S},5~{R})-2-(4-azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolane-2-carbonitrile, Sodium/nucleoside cotransporter | Authors: | Wright, N.J, Lee, S.-Y. | Deposit date: | 2023-08-26 | Release date: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Antiviral drug recognition and elevator-type transport motions of CNT3. Nat.Chem.Biol., 2024
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6OO5
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![BU of 6oo5 by Molmil](/molmil-images/mine/6oo5) | Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in amphipol resolved to 4.2 A | Descriptor: | TRPV2, resiniferatoxin | Authors: | Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | Deposit date: | 2019-04-22 | Release date: | 2019-05-29 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes. Elife, 8, 2019
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6OT2
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![BU of 6ot2 by Molmil](/molmil-images/mine/6ot2) | Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 A resolution | Descriptor: | Transient receptor potential cation channel subfamily V member 3 | Authors: | Zubcevic, L, Borschel, W.F, Hsu, A.L, Borgnia, M.J, Lee, S.-Y. | Deposit date: | 2019-05-02 | Release date: | 2019-05-22 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Regulatory switch at the cytoplasmic interface controls TRPV channel gating. Elife, 8, 2019
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8H2D
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8H0H
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5GWP
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![BU of 5gwp by Molmil](/molmil-images/mine/5gwp) | Crystal structure of RCAR3:PP2C wild-type with (+)-ABA | Descriptor: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, ABA receptor RCAR3, MAGNESIUM ION, ... | Authors: | Han, S, Lee, S. | Deposit date: | 2016-09-12 | Release date: | 2017-09-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.577 Å) | Cite: | Modulation of ABA Signaling by Altering VxG Phi L Motif of PP2Cs in Oryza sativa. Mol Plant, 10, 2017
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5GWO
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![BU of 5gwo by Molmil](/molmil-images/mine/5gwo) | Crystal structure of RCAR3:PP2C S265F/I267M with (+)-ABA | Descriptor: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, ABA receptor RCAR3, MAGNESIUM ION, ... | Authors: | Han, S, Lee, S. | Deposit date: | 2016-09-12 | Release date: | 2017-09-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.816 Å) | Cite: | Modulation of ABA Signaling by Altering VxG Phi L Motif of PP2Cs in Oryza sativa. Mol Plant, 10, 2017
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8E4L
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![BU of 8e4l by Molmil](/molmil-images/mine/8e4l) | The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2 | Descriptor: | 3-isothiocyanatoprop-1-ene, CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, ... | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | Deposit date: | 2022-08-18 | Release date: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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8E4O
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![BU of 8e4o by Molmil](/molmil-images/mine/8e4o) | The closed C1-state mouse TRPM8 structure in complex with putative PI(4,5)P2 | Descriptor: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | Deposit date: | 2022-08-18 | Release date: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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8E4N
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![BU of 8e4n by Molmil](/molmil-images/mine/8e4n) | The closed C1-state mouse TRPM8 structure in complex with PI(4,5)P2 | Descriptor: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | Deposit date: | 2022-08-18 | Release date: | 2022-10-26 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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8E4Q
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![BU of 8e4q by Molmil](/molmil-images/mine/8e4q) | The closed C0-state flycatcher TRPM8 structure in complex with PI(4,5)P2 | Descriptor: | Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | Deposit date: | 2022-08-18 | Release date: | 2022-10-26 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.51 Å) | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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8E4P
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![BU of 8e4p by Molmil](/molmil-images/mine/8e4p) | Mouse TRPM8 structure determined in the ligand- and PI(4,5)P2-free condition, Class I , C0 state | Descriptor: | CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | Deposit date: | 2022-08-18 | Release date: | 2022-10-26 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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8E4M
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![BU of 8e4m by Molmil](/molmil-images/mine/8e4m) | The intermediate C2-state mouse TRPM8 structure in complex with the cooling agonist C3 and PI(4,5)P2 | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | Deposit date: | 2022-08-18 | Release date: | 2022-10-26 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
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3TIJ
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![BU of 3tij by Molmil](/molmil-images/mine/3tij) | Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae | Descriptor: | DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, SODIUM ION, ... | Authors: | Johnson, Z.L, Cheong, C.-G, Lee, S.-Y. | Deposit date: | 2011-08-20 | Release date: | 2012-03-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.436 Å) | Cite: | Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4A Nature, 483, 2012
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3AY3
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8FC7
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![BU of 8fc7 by Molmil](/molmil-images/mine/8fc7) | Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745 | Descriptor: | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Kwon, D.H, Lee, S.-Y, Zhang, F. | Deposit date: | 2022-12-01 | Release date: | 2023-07-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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8FC9
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![BU of 8fc9 by Molmil](/molmil-images/mine/8fc9) | Cryo-EM structure of the human TRPV4 - RhoA, apo condition | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA, ... | Authors: | Kwon, D.H, Lee, S.-Y, Zhang, F. | Deposit date: | 2022-12-01 | Release date: | 2023-07-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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8FC8
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![BU of 8fc8 by Molmil](/molmil-images/mine/8fc8) | Cryo-EM structure of the human TRPV4 in complex with GSK1016790A | Descriptor: | CHOLESTEROL HEMISUCCINATE, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4 | Authors: | Kwon, D.H, Lee, S.-Y, Zhang, F. | Deposit date: | 2022-12-01 | Release date: | 2023-07-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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