7WQS
 
 | | Crystal structure of Aldo-keto reductase 1C3 complexed with compound 25 | | Descriptor: | 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-~{N}-(3-methoxyphenyl)benzamide, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Sun, H, Fang, P. | | Deposit date: | 2022-01-26 | | Release date: | 2023-01-04 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer.
Eur.J.Med.Chem., 247, 2022
|
|
7WQM
 | | Crystal structure of Aldo-keto reductase 1C3 complexed with compound 24 | | Descriptor: | 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-~{N}-(2-methoxyphenyl)benzamide, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Sun, H, Fang, P. | | Deposit date: | 2022-01-25 | | Release date: | 2023-01-04 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer.
Eur.J.Med.Chem., 247, 2022
|
|
5W59
 | |
7XTO
 | |
5VKI
 | | Crystal structure of P[19] rotavirus VP8* complexed with mucin core 2 | | Descriptor: | GLYCEROL, Outer capsid protein VP4, SULFATE ION, ... | | Authors: | Xu, S, Liu, Y, Woodruff, A, Zhong, W, Jiang, X, Kennedy, M.A. | | Deposit date: | 2017-04-21 | | Release date: | 2017-11-08 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis of glycan specificity of P[19] VP8*: Implications for rotavirus zoonosis and evolution.
PLoS Pathog., 13, 2017
|
|
5VKS
 | | Crystal structure of P[19] rotavirus VP8* complexed with LNFPI | | Descriptor: | GLYCEROL, Outer capsid protein VP4, SULFATE ION, ... | | Authors: | Xu, S, Liu, Y, Woodruff, A, Zhong, W, Jiang, X, Kennedy, M.A. | | Deposit date: | 2017-04-22 | | Release date: | 2017-11-08 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Structural basis of glycan specificity of P[19] VP8*: Implications for rotavirus zoonosis and evolution.
PLoS Pathog., 13, 2017
|
|
3S9Y
 | | Crystal Structure of P. falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP in space group P21, produced from 5-fluoro-6-azido-UMP | | Descriptor: | 6-amino-5-fluorouridine 5'-(dihydrogen phosphate), DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, ... | | Authors: | Liu, Y, Kotra, L.P, Pai, E.F. | | Deposit date: | 2011-06-02 | | Release date: | 2012-04-18 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.
J.Med.Chem., 52, 2009
|
|
6ASG
 | | Crystal structure of Thermus thermophilus RNA polymerase core enzyme | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Liu, Y, Lin, W, Ying, R, Ebright, R.H. | | Deposit date: | 2017-08-24 | | Release date: | 2018-04-11 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).
Mol. Cell, 70, 2018
|
|
6L0O
 | | WH domain of human MCM8 | | Descriptor: | DNA helicase MCM8, SULFATE ION | | Authors: | Liu, Y, Li, J, Liu, L, Zeng, H. | | Deposit date: | 2019-09-26 | | Release date: | 2020-04-29 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.21 Å) | | Cite: | Crystal structure of the winged-helix domain of MCM8.
Biochem.Biophys.Res.Commun., 526, 2020
|
|
5ZBM
 | |
5ZBN
 | |
5YYS
 | | Cryo-EM structure of L-fucokinase, GDP-fucose pyrophosphorylase (FKP)in Bacteroides fragilis | | Descriptor: | L-fucokinase, L-fucose-1-P guanylyltransferase | | Authors: | Wang, J, Hu, H, Liu, Y, Zhou, Q, Wu, P, Yan, N, Wang, H.W, Wu, J.W, Sun, L. | | Deposit date: | 2017-12-11 | | Release date: | 2018-12-12 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase (FKP) in Bacteroides fragilis.
Protein Cell, 10, 2019
|
|
6MLC
 | | PHD6 domain of MLL3 in complex with histone H4 | | Descriptor: | GLYCEROL, Histone H4, Histone-lysine N-methyltransferase 2C, ... | | Authors: | Dong, A, Liu, Y, Qin, S, Lei, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2018-09-27 | | Release date: | 2018-10-24 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
Nat Commun, 10, 2019
|
|
6C9K
 | | Single-Particle reconstruction of DARP14 - A designed protein scaffold displaying ~17kDa DARPin proteins | | Descriptor: | DARP14 - Subunit A with DARPin, DARP14 - Subunit B | | Authors: | Gonen, S, Liu, Y, Yeates, T.O, Gonen, T. | | Deposit date: | 2018-01-26 | | Release date: | 2018-03-21 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
6C9I
 | | Single-Particle reconstruction of DARP14 - A designed protein scaffold displaying ~17kDa DARPin proteins - Scaffold | | Descriptor: | DARP14 - Subunit A with DARPin, DARP14 - Subunit B | | Authors: | Gonen, S, Liu, Y, Yeates, T.O, Gonen, T. | | Deposit date: | 2018-01-26 | | Release date: | 2018-03-21 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Near-atomic cryo-EM imaging of a small protein displayed on a designed scaffolding system.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
7EA8
 | |
7EA5
 | |
7XC5
 | | Crystal structure of the ANK domain of CLPB | | Descriptor: | Isoform 2 of Caseinolytic peptidase B protein homolog | | Authors: | Liu, Y, Wu, D, Lu, G, Gao, N, Lin, J. | | Deposit date: | 2022-03-23 | | Release date: | 2023-01-18 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Comprehensive structural characterization of the human AAA+ disaggregase CLPB in the apo- and substrate-bound states reveals a unique mode of action driven by oligomerization.
Plos Biol., 21, 2023
|
|
7W30
 | | Tudor domain of SMN in complex with a small molecule | | Descriptor: | 1,2-dimethylquinolin-4-imine, Survival motor neuron protein, UNKNOWN ATOM OR ION | | Authors: | Li, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Liu, Y, Min, J. | | Deposit date: | 2021-11-24 | | Release date: | 2022-10-05 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.
Nat Commun, 13, 2022
|
|
7W2P
 | | Tudor domain of SMN in complex with a small molecule | | Descriptor: | 2-[(4-fluorophenyl)methyl]-2-azatricyclo[7.3.0.0^{3,7}]dodeca-1(9),3(7)-dien-8-imine, MAGNESIUM ION, Survival motor neuron protein, ... | | Authors: | Li, W, Arrowsmith, C.H, Edwards, A.M, Liu, Y, Min, J. | | Deposit date: | 2021-11-24 | | Release date: | 2022-10-05 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.
Nat Commun, 13, 2022
|
|
7D3W
 | |
7D3X
 | |
7WM3
 | | hnRNP A2/B1 RRMs in complex with single-stranded DNA | | Descriptor: | DNA (5'-D(P*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3'), Heterogeneous nuclear ribonucleoproteins A2/B1 | | Authors: | Abula, A, Liu, Y, Guo, H, Li, T, Ji, X. | | Deposit date: | 2022-01-14 | | Release date: | 2022-06-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition.
J.Mol.Biol., 435, 2022
|
|
8K58
 | | The cryo-EM map of close TIEA-TIC complex | | Descriptor: | 15 kDa RNA polymerase-binding protein, DNA (29-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Zhang, K.N, Liu, Y, Chen, M, Wang, Y, Lin, W, Li, M, Zhang, X, Gao, Y, Gong, Q, Chen, H, Steve, M, Li, S, Zhang, K, Liu, B. | | Deposit date: | 2023-07-21 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | TIEA inhibits Sigma70-dependent transcriptions, accelerates elongation speed and elevates transcription error
To Be Published
|
|
8K5A
 | | The cryo-EM map of open TIEA-TIC complex | | Descriptor: | 15 kDa RNA polymerase-binding protein, DNA (29-MER), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Zhang, K.N, Liu, Y, Chen, M, Wang, Y, Lin, W, Li, M, Zhang, X, Gao, Y, Gong, Q, Chen, H, Steve, M, Li, S, Zhang, K, Liu, B. | | Deposit date: | 2023-07-21 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | TIEA inhibits sigma70-dependent transcriptions, accelerates elongation speed and elevates transcription error
To Be Published
|
|
