6L0O

WH domain of human MCM8

Summary for 6L0O

• Entry DOI: 10.2210/pdb6l0o/pdb
• Descriptor: DNA helicase MCM8, SULFATE ION (3 entities in total)
• Functional Keywords: whd, winged helix, dna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 9743.98

Authors

Liu, Y.,Li, J.,Liu, L.,Zeng, H. (deposition date: 2019-09-26, release date: 2020-04-29, Last modification date: 2024-03-27)

Primary citation

Zeng, H.,Li, J.,Xu, H.,Li, H.,Liu, Y.
Crystal structure of the winged-helix domain of MCM8.
Biochem.Biophys.Res.Commun., 526:993-998, 2020

PubMed Abstract: Minichromosome maintenance 8 (MCM8) is a recently identified member of the minichromosome maintenance family, which possesses helicase and ATPase activity. It interacts with MCM9 and participates in homologous recombination repair. The structure of MCM8 is unclear now. Here, we report the crystal structure of the winged-helix domain of human MCM8 (MCM8-WHD) at 1.21 Å resolution. MCM8-WHD adopts a conserved winged-helix architecture. Structure analysis and biochemical study results showed the DNA binding ability and crucial residues of MCM8-WHD. Our results are helpful to understand the function of MCM8.

PubMed: 32295713
DOI: 10.1016/j.bbrc.2020.03.150

Experimental method

X-RAY DIFFRACTION (1.21 Å)