3S9Y

Crystal Structure of P. falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP in space group P21, produced from 5-fluoro-6-azido-UMP

Summary for 3S9Y

Related2Q8L 2Q8Z 2QAF 3BAR 3BPW 3MWA 3N34
DescriptorOrotidine 5'-phosphate decarboxylase, 6-amino-5-fluorouridine 5'-(dihydrogen phosphate), SULFATE ION, ... (7 entities in total)
Functional Keywordsp. falciparum, orotidine 5'-monophosphate decarboxylase, 5-fluoro-6-amino-ump, 5-fluoro-6-azido-ump, decarboxylase, lyase
Biological sourcePlasmodium falciparum
Total number of polymer chains4
Total molecular weight161943.59
Authors
Liu, Y.,Kotra, L.P.,Pai, E.F. (deposition date: 2011-06-02, release date: 2012-04-18)
Primary citation
Bello, A.M.,Konforte, D.,Poduch, E.,Furlonger, C.,Wei, L.,Liu, Y.,Lewis, M.,Pai, E.F.,Paige, C.J.,Kotra, L.P.
Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.
J.Med.Chem., 52:1648-1658, 2009
PubMed: 19260677 (PDB entries with the same primary citation)
DOI: 10.1021/jm801224t
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20170.1%2.0%3.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution