3S9Y

Crystal Structure of P. falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP in space group P21, produced from 5-fluoro-6-azido-UMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Orotidine 5'-phosphate decarboxylase	polymer	342	39899.5	4	UniProt (Q8IJH3) Pfam (PF00215) In PDB	Plasmodium falciparum
2	A, B, C, D	6-amino-5-fluorouridine 5'-(dihydrogen phosphate)	non-polymer		357.2	4	Chemie (FNU)
3	B	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	B	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
5	B	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
6	B, C	HEXAETHYLENE GLYCOL	non-polymer		282.3	2	Chemie (P6G)
7		water	water		18.0	1131	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 323 (UniProt: Q8IJH3)

PDB	External Database	Details
Met -18	-	expression tag
Gly -17	-	expression tag
Ser -16	-	expression tag
Ser -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
Ser -8	-	expression tag
Ser -7	-	expression tag
Gly -6	-	expression tag
Leu -5	-	expression tag
Val -4	-	expression tag
Pro -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	159597.8
Non-Polymers*	Number of molecules	9
	Total formula weight	2345.8
All*	Total formula weight	161943.6

*Water molecules are not included.