3S9Y
Crystal Structure of P. falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP in space group P21, produced from 5-fluoro-6-azido-UMP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
A | 0005515 | molecular_function | protein binding |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0016831 | molecular_function | carboxy-lyase activity |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
B | 0005515 | molecular_function | protein binding |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0016831 | molecular_function | carboxy-lyase activity |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
C | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
C | 0005515 | molecular_function | protein binding |
C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
C | 0016831 | molecular_function | carboxy-lyase activity |
C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
D | 0004590 | molecular_function | orotidine-5'-phosphate decarboxylase activity |
D | 0005515 | molecular_function | protein binding |
D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
D | 0016831 | molecular_function | carboxy-lyase activity |
D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE FNU A 324 |
Chain | Residue |
A | ASP23 |
A | PRO264 |
A | GLN269 |
A | GLY293 |
A | ARG294 |
A | HOH329 |
A | HOH330 |
A | HOH334 |
A | HOH338 |
A | HOH339 |
A | HOH378 |
A | LYS102 |
B | ASP141 |
B | ILE142 |
B | THR145 |
A | ASN104 |
A | ASP136 |
A | LYS138 |
A | LEU191 |
A | THR194 |
A | THR195 |
A | VAL240 |
site_id | AC2 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE FNU B 324 |
Chain | Residue |
A | ASP141 |
A | ILE142 |
A | THR145 |
B | ASP23 |
B | LYS102 |
B | ASN104 |
B | ASP136 |
B | LYS138 |
B | LEU191 |
B | THR194 |
B | THR195 |
B | VAL240 |
B | PRO264 |
B | GLN269 |
B | GLY293 |
B | ARG294 |
B | HOH326 |
B | HOH341 |
B | HOH349 |
B | HOH353 |
B | HOH355 |
B | HOH385 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 B 2000 |
Chain | Residue |
B | LYS147 |
B | ARG150 |
B | ASP179 |
B | GLU180 |
B | GLU181 |
B | HOH415 |
B | HOH678 |
B | HOH972 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PGE B 3000 |
Chain | Residue |
B | ASN299 |
B | TYR301 |
C | ASN299 |
C | TYR301 |
C | ALA305 |
C | MET308 |
site_id | AC5 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE PEG B 3001 |
Chain | Residue |
A | ILE142 |
A | GLY143 |
A | ASN171 |
A | HOH404 |
B | THR195 |
B | ASN196 |
B | PRO197 |
B | GLN269 |
B | HOH467 |
B | HOH468 |
B | HOH605 |
site_id | AC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE P6G B 3003 |
Chain | Residue |
B | TYR251 |
B | TYR255 |
B | HOH466 |
B | HOH559 |
B | HOH1094 |
C | LYS174 |
C | MET224 |
C | TYR227 |
C | HOH620 |
D | HOH870 |
site_id | AC7 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE FNU C 324 |
Chain | Residue |
D | ILE142 |
D | THR145 |
C | ASP23 |
C | LYS102 |
C | ASN104 |
C | ASP136 |
C | LYS138 |
C | LEU191 |
C | THR194 |
C | THR195 |
C | VAL240 |
C | PRO264 |
C | GLN269 |
C | GLY293 |
C | ARG294 |
C | HOH325 |
C | HOH327 |
C | HOH335 |
C | HOH346 |
C | HOH352 |
C | HOH353 |
D | ASP141 |
site_id | AC8 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE P6G C 3002 |
Chain | Residue |
A | ASN205 |
B | LYS174 |
B | MET224 |
B | TYR227 |
C | ASP209 |
C | TYR251 |
C | TYR255 |
C | HOH386 |
C | HOH416 |
C | HOH657 |
C | HOH714 |
C | HOH767 |
C | HOH1078 |
site_id | AC9 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE FNU D 324 |
Chain | Residue |
C | ASP141 |
C | ILE142 |
C | THR145 |
D | ASP23 |
D | LYS102 |
D | ASN104 |
D | ASP136 |
D | LYS138 |
D | LEU191 |
D | THR194 |
D | THR195 |
D | VAL240 |
D | PRO264 |
D | GLN269 |
D | GLY293 |
D | ARG294 |
D | HOH325 |
D | HOH328 |
D | HOH330 |
D | HOH334 |
D | HOH335 |
D | HOH346 |
Functional Information from PROSITE/UniProt
site_id | PS00156 |
Number of Residues | 14 |
Details | OMPDECASE Orotidine 5'-phosphate decarboxylase active site. TIlDmKinDIGnTV |
Chain | Residue | Details |
A | THR133-VAL146 |