2QAF

Crystal structure of Plasmodium falciparum orotidine 5'-phosphate decarboxylase covalently modified by 6-iodo-UMP

Summary for 2QAF

• Entry DOI: 10.2210/pdb2qaf/pdb
• Related: 2Q8L 2Q8Z
• Descriptor: Orotidine 5' monophosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE, SULFATE ION, ... (4 entities in total)
• Functional Keywords: plasmodium falciparum, orotidine 5'-phosphate decarboxylase, covalently, 6-iodo-ump, lyase
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 2
• Total formula weight: 80543.34

Authors

Liu, Y.,Lau, W.,Bello, A.M.,Kotra, L.P.,Hui, R.,Pai, E.F. (deposition date: 2007-06-15, release date: 2008-04-29, Last modification date: 2023-08-30)

• Primary citation: Bello, A.M.,Poduch, E.,Liu, Y.,Wei, L.,Crandall, I.,Wang, X.,Dyanand, C.,Kain, K.C.,Pai, E.F.,Kotra, L.P.; Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase; J.Med.Chem., 51:439-448, 2008; PubMed: 18189347; DOI: 10.1021/jm7010673

Experimental method

X-RAY DIFFRACTION (1.95 Å)