3BAR

Crystal structure of Plasmodium falciparum orotidine 5'-phosphate decarboxylase covalently modified by 6-azido-UMP

Summary for 3BAR

Entry DOI	10.2210/pdb3bar/pdb
Related	2Q8L 2Q8Z 2QAF
Descriptor	Orotidine 5'-phosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE (3 entities in total)
Functional Keywords	plasmodium falciparum, orotidine 5'-phosphate decarboxylase, covalently, 6-azido-ump, lyase, pyrimidine biosynthesis
Biological source	Plasmodium falciparum
Total number of polymer chains	2
Total formula weight	80447.28
Authors	Liu, Y.,Bello, A.M.,Poduch, E.,Lau, W.,Kotra, L.P.,Pai, E.F. (deposition date: 2007-11-08, release date: 2008-01-29, Last modification date: 2023-08-30)
Primary citation	Bello, A.M.,Poduch, E.,Liu, Y.,Wei, L.,Crandall, I.,Wang, X.,Dyanand, C.,Kain, K.C.,Pai, E.F.,Kotra, L.P. Structure-Activity Relationships of C6-Uridine Derivatives Targeting Plasmodia Orotidine Monophosphate Decarboxylase. J.Med.Chem., 51:439-448, 2008 Cited by PubMed: 18189347 DOI: 10.1021/jm7010673 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation