3BAR

Crystal structure of Plasmodium falciparum orotidine 5'-phosphate decarboxylase covalently modified by 6-azido-UMP

Summary for 3BAR

Related2Q8L 2Q8Z 2QAF
DescriptorOrotidine 5'-phosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE (3 entities in total)
Functional Keywordsplasmodium falciparum, orotidine 5'-phosphate decarboxylase, covalently, 6-azido-ump, lyase, pyrimidine biosynthesis
Biological sourcePlasmodium falciparum
Total number of polymer chains2
Total molecular weight80447.28
Authors
Liu, Y.,Bello, A.M.,Poduch, E.,Lau, W.,Kotra, L.P.,Pai, E.F. (deposition date: 2007-11-08, release date: 2008-01-29, Last modification date: 2011-07-13)
Primary citation
Bello, A.M.,Poduch, E.,Liu, Y.,Wei, L.,Crandall, I.,Wang, X.,Dyanand, C.,Kain, K.C.,Pai, E.F.,Kotra, L.P.
Structure-Activity Relationships of C6-Uridine Derivatives Targeting Plasmodia Orotidine Monophosphate Decarboxylase.
J.Med.Chem., 51:439-448, 2008
PubMed: 18189347 (PDB entries with the same primary citation)
DOI: 10.1021/jm7010673
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21960 2.0% 4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
170172
PDB entries from 2020-10-21