4B7T

Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Leucettine L4

4B7T の概要

• エントリーDOI: 10.2210/pdb4b7t/pdb
• 関連するPDBエントリー: 1DK8 1EMU 1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2UW9 2X37 2X39 2XH5 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4ACH 4AFJ 4B0K 4B0L
• 分子名称: GLYCOGEN SYNTHASE KINASE-3 BETA, AXIN-1, (5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-methyl-2-(propan-2-ylamino)imidazol-4-one, ... (4 entities in total)
• 機能のキーワード: transferase-peptide complex, transferase, insulin pathway, wnt signaling pathway, inhibitor, transferase/peptide
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42229.53

構造登録者

Oberholzer, A.E.,Pearl, L.H. (登録日: 2012-08-22, 公開日: 2013-01-30, 最終更新日: 2023-12-20)

• 主引用文献: Tahtouh, T.,Elkins, J.M.,Filippakopoulos, P.,Soundararajan, M.,Burgy, G.,Durieu, E.,Cochet, C.,Schmid, R.S.,Lo, D.C.,Delhommel, F.,Oberholzer, A.E.,Pearl, L.H.,Carreaux, F.,Bazureau, J.,Knapp, S.,Meijer, L.; Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B.; J.Med.Chem., 55:9312-, 2012; PubMed: 22998443; DOI: 10.1021/JM301034U

実験手法

X-RAY DIFFRACTION (2.772 Å)